genome. Inhibition of these parasitespecific protein-protein interactions could thus serve as promising drug targets with possibly few or 15155536 no side-effects. through the MedChemExpress Halofuginone automated analysis using the SAFE software and verified by backward BLAST, and for which functional annotation is available for both proteins. The results are grouped by organism and the common fusion events between the organisms are marked with a distinct color in the second column. A description of each protein that is involved in the fusion event is also shown, along with the ORF numbers, and the Protein IDs. The table also contains information from the BLAST analysis, displaying the percentage of identities, and the e-value of each result. In the Description column, there is a short description of each event. The description is highlighted in yellow when the two proteins have been previously reported to interact or co-exist in a protein complex, with the respective references shown; the symbol designates participation in the same biological pathway. Finally, the last column displays information about the fate of the protein pair in Homo sapiens: f: the protein pair is fused, s: the protein pair is separate, a/b: only one part of the fused protein is conserved in humans, either the first or the second, f/s: the protein pair is found in both fused and separate configurations. Fusion events detected in this study, for which no functional annotation is available. This table includes all the protein pairs that were found to participate in fusion events through the automated analysis using the SAFE software and verified by backward BLAST, and for which no functional annotation is available for either protein, i.e. both are designated as “hypothetical”. Data are shown/marked as described in the legend for The oxygenated metabolites of arachidonic acid comprise a large family of bioactive lipids that have diverse roles in regulating homeostatic processes and in modulating inflammation and immune responses. The production of eicosanoids is initiated by the release of arachidonic acid that is metabolized through the 5-lipoxygenase pathway to leukotrienes and by cyclooxygenases to prostanoids and thromboxane. Eicosanoids are secreted and act locally in an autocrine or paracrine fashion through interaction with specific G-protein coupled receptors to exert their biological effects. Leukotrienes are pro-inflammatory mediators but prostaglandins have pro- and antiinflammatory effects depending on the cell type-specific GPCRdependent signal transduction pathways that are triggered. Macrophages are an important source of eicosanoids that are produced rapidly in response to stimulation by bacterial and fungal pathogens. Resident tissue macrophages are a first line of defense against invading microorganisms that are recognized by pattern recognition receptors that engage microbial surface structures. We have used resident mouse 1 cPLA2 Regulates Gene Expression in Macrophages peritoneal macrophages to study the regulation of eicosanoid production in response 22634634 to the model fungal agonist zymosan, cell wall particles of Saccharomyces cerevisiae. Zymosan stimulates activation of the Group IVA cytosolic phospholipase A2, the first key regulatory enzyme in RPM that releases arachidonic acid for eicosanoid 
production. To identify the pattern recognition receptors on RPM that mediate cPLA2 activation and eicosanoid production, the more medically relevant fungal pathogen Candida albicans was s
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