Product Name :
Rabbit anti-ERF3B Polyclonal Antibody(Center)
Synonym :
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b; eRF3b; G1 to S phase transition protein 2 homolog; GSPT2; ERF3B
Host :
Rabbit
Species Reactivity:
Human, Mouse
Specificity :
This ERF3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human ERF3B.
Predicted Reactivity:
Applications :
WB~~1:1000
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
ERF3B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Background :
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
UniProt :
Q8IYD1
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b; eRF3b; G1 to S phase transition protein 2 homolog; GSPT2; ERF3B |Host Rabbit |Specificity This ERF3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human ERF3B. |Species Reactivity Human, Mouse |Applications WB~~1:1000 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas ERF3B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |Target |Background Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. |Cellular localization Cytoplasm. |UniProt Q8IYD1 |References |References Cheng, Z., et al. Genes Dev. 23(9):1106-1118(2009)Zhouravleva, G., et al. IUBMB Life 58(4):199-202(2006)Chauvin, C., et al. Mol. Cell. Biol. 25(14):5801-5811(2005)Hoshino, S., et al. J. Biol. Chem. 274(24):16677-16680(1999)Hansen, L.L., et al. Cytogenet. Cell Genet. 86 (3-4), 250-251 (1999) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-ERF3B Polyclonal Antibody(Center)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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