Product Name :
MK-8353
Description:
MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.
CAS:
1184173-73-6
Molecular Weight:
691.84
Formula:
C37H41N9O3S
Chemical Name:
(3S)-1-(2-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1,2,3,6-tetrahydropyridin-1-yl-2-oxoethyl)-3-(methylsulfanyl)-N-3-[6-(propan-2-yloxy)pyridin-3-yl]-1H-indazol-5-ylpyrrolidine-3-carboxamide
Smiles :
CN1C=NC(=N1)C1C=CC(=CC=1)C1CCN(CC=1)C(=O)CN1C[C@](CC1)(SC)C(=O)NC1=CC2C(=NNC=2C=C1)C1C=NC(=CC=1)OC(C)C
InChiKey:
KPQQGHGDBBJGFA-QNGWXLTQSA-N
InChi :
InChI=1S/C37H41N9O3S/c1-24(2)49-32-12-9-28(20-38-32)34-30-19-29(10-11-31(30)41-42-34)40-36(48)37(50-4)15-18-45(22-37)21-33(47)46-16-13-26(14-17-46)25-5-7-27(8-6-25)35-39-23-44(3)43-35/h5-13,19-20,23-24H,14-18,21-22H2,1-4H3,(H,40,48)(H,41,42)/t37-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.|Product information|CAS Number: 1184173-73-6|Molecular Weight: 691.84|Formula: C37H41N9O3S|Chemical Name: (3S)-1-(2-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1,2,3,6-tetrahydropyridin-1-yl-2-oxoethyl)-3-(methylsulfanyl)-N-3-[6-(propan-2-yloxy)pyridin-3-yl]-1H-indazol-5-ylpyrrolidine-3-carboxamide|Smiles: CN1C=NC(=N1)C1C=CC(=CC=1)C1CCN(CC=1)C(=O)CN1C[C@](CC1)(SC)C(=O)NC1=CC2C(=NNC=2C=C1)C1C=NC(=CC=1)OC(C)C|InChiKey: KPQQGHGDBBJGFA-QNGWXLTQSA-N|InChi: InChI=1S/C37H41N9O3S/c1-24(2)49-32-12-9-28(20-38-32)34-30-19-29(10-11-31(30)41-42-34)40-36(48)37(50-4)15-18-45(22-37)21-33(47)46-16-13-26(14-17-46)25-5-7-27(8-6-25)35-39-23-44(3)43-35/h5-13,19-20,23-24H,14-18,21-22H2,1-4H3,(H,40,48)(H,41,42)/t37-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (180.Crystal Violet supplier 68 mM; Need ultrasonic).Methyl cellulose Biochemical Assay Reagents |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:31634248 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. MK-8353 only at 1 μM shows >50% inhibition on 3 kinases (CLK2, FLT4, and Aurora B), and no other kinases tested are inhibited by >35% at 0.1 μM. MK-8353 also shows potent antitumor activity against various cancer cell lines, such Malme-3M cells (Melanoma), Colo-205 cells (Colon), NCI-H292 cells (Lung), A-549 cells (NSCLC), 8505C cells (Thyroid), SW-626 cells (Ovarian), with EC50s of 21 nM, 19 nM, 130 nM, 230 nM, 210 nM, 108 nM.|In Vivo:|MK-8353 (60 mg/kg, p.o., bid (twice daily)) causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells, including LOX, Colo-205, MIA PaCa-2, and Calu-6 cells.|Products are for research use only. Not for human use.|