Product Name :
KU-32
Description:
KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.
CAS:
956498-70-7
Molecular Weight:
407.41
Formula:
C20H25NO8
Chemical Name:
N-(7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy-8-methyl-2-oxo-2H-chromen-3-yl)acetamide
Smiles :
CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](OC2=CC=C3C=C(NC(C)=O)C(=O)OC3=C2C)OC1(C)C
InChiKey:
KJAWXHNSLFJNTM-BUIAKZPTSA-N
InChi :
InChI=1S/C20H25NO8/c1-9-13(27-19-15(24)14(23)17(26-5)20(3,4)29-19)7-6-11-8-12(21-10(2)22)18(25)28-16(9)11/h6-8,14-15,17,19,23-24H,1-5H3,(H,21,22)/t14-,15+,17+,19+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Zilovertamab manufacturer
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.|Product information|CAS Number: 956498-70-7|Molecular Weight: 407.41|Formula: C20H25NO8|Chemical Name: N-(7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy-8-methyl-2-oxo-2H-chromen-3-yl)acetamide|Smiles: CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](OC2=CC=C3C=C(NC(C)=O)C(=O)OC3=C2C)OC1(C)C|InChiKey: KJAWXHNSLFJNTM-BUIAKZPTSA-N|InChi: InChI=1S/C20H25NO8/c1-9-13(27-19-15(24)14(23)17(26-5)20(3,4)29-19)7-6-11-8-12(21-10(2)22)18(25)28-16(9)11/h6-8,14-15,17,19,23-24H,1-5H3,(H,21,22)/t14-,15+,17+,19+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Imdevimab Purity & Documentation |Shelf Life: ≥12 months if stored properly.PMID:31643326 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Treating human islets with KU-32 for 24 hours shows no toxicity. With a minimum of 2-day exposure, KU-32 improves cellular viability by blocking apoptosis. Functionally, isolated human islets release more glucose-stimulated insulin when preincubate in KU-32. KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro.|In Vivo:|Diabetic BKS-db/db mice, a model for type 2 diabetes, administered KU-32 for 10 weeks do not show any significant changes in blood glucose and insulin levels, despite having greater insulin staining/beta cell in the pancreas compared to untreated BKS db/db mice.|Products are for research use only. Not for human use.|