Product Name :
Org-12962 hydrochloride
Description:
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.
CAS:
210821-63-9
Molecular Weight:
302.12
Formula:
C10H12Cl2F3N3
Chemical Name:
1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine hydrochloride
Smiles :
Cl.FC(F)(F)C1C=CC(=NC=1Cl)N1CCNCC1
InChiKey:
FVDILXYXZAAJOS-UHFFFAOYSA-N
InChi :
InChI=1S/C10H11ClF3N3.ClH/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17;/h1-2,15H,3-6H2;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.|Product information|CAS Number: 210821-63-9|Molecular Weight: 302.12|Formula: C10H12Cl2F3N3|Chemical Name: 1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine hydrochloride|Smiles: Cl.FC(F)(F)C1C=CC(=NC=1Cl)N1CCNCC1|InChiKey: FVDILXYXZAAJOS-UHFFFAOYSA-N|InChi: InChI=1S/C10H11ClF3N3.ClH/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17;/h1-2,15H,3-6H2;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bliretrigine} site|{Bliretrigine} Sodium Channel|{Bliretrigine} Protocol|{Bliretrigine} In Vivo|{Bliretrigine} custom synthesis|{Bliretrigine} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{GMP EGF Protein, Human} web|{GMP EGF Protein, Human} Technical Information|{GMP EGF Protein, Human} In stock|{GMP EGF Protein, Human} manufacturer|{GMP EGF Protein, Human} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24360118 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects.|Products are for research use only. Not for human use.|