Product Name :
NSC-87877
Description:
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).
CAS:
56990-57-9
Molecular Weight:
459.45
Formula:
C19H13N3O7S2
Chemical Name:
8-oxo-7-[2-(6-sulfonaphthalen-2-yl)hydrazin-1-ylidene]-7,8-dihydroquinoline-5-sulfonic acid
Smiles :
OS(=O)(=O)C1=CC(=NNC2=CC3C=CC(=CC=3C=C2)S(O)(=O)=O)C(=O)C2N=CC=CC1=2
InChiKey:
BIQBDHSYQMHHPU-CJLVFECKSA-N
InChi :
InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,21H,(H,24,25,26)(H,27,28,29)/b22-16+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively.{{Milbemycin oxime} web|{Milbemycin oxime} Anti-infection|{Milbemycin oxime} Purity & Documentation|{Milbemycin oxime} Purity|{Milbemycin oxime} custom synthesis|{Milbemycin oxime} Autophagy} NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).{{Pibrentasvir} web|{Pibrentasvir} HCV|{Pibrentasvir} Purity & Documentation|{Pibrentasvir} Description|{Pibrentasvir} custom synthesis|{Pibrentasvir} Epigenetics} |Product information|CAS Number: 56990-57-9|Molecular Weight: 459.45|Formula: C19H13N3O7S2|Chemical Name: 8-oxo-7-[2-(6-sulfonaphthalen-2-yl)hydrazin-1-ylidene]-7,8-dihydroquinoline-5-sulfonic acid|Smiles: OS(=O)(=O)C1=CC(=NNC2=CC3C=CC(=CC=3C=C2)S(O)(=O)=O)C(=O)C2N=CC=CC1=2|InChiKey: BIQBDHSYQMHHPU-CJLVFECKSA-N|InChi: InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,21H,(H,24,25,26)(H,27,28,29)/b22-16+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (54.PMID:23557924 41 mM; ultrasonic and warming and heat to 60°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines. NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation.|In Vivo:|NSC-87877 (30 mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity.|Products are for research use only. Not for human use.|