Product Name :
D-3263 hydrochloride
Description:
D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.
CAS:
1008763-54-9
Molecular Weight:
409.95
Formula:
C21H32ClN3O3
Chemical Name:
3-(2-aminoethyl)-5-methoxy-1-[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexanecarbonyl]-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride
Smiles :
Cl.CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)N1C2=CC=C(C=C2N(CCN)C1=O)OC
InChiKey:
DYMRNRVXSXCQHZ-UANXYBPYSA-N
InChi :
InChI=1S/C21H31N3O3.ClH/c1-13(2)16-7-5-14(3)11-17(16)20(25)24-18-8-6-15(27-4)12-19(18)23(10-9-22)21(24)26;/h6,8,12-14,16-17H,5,7,9-11,22H2,1-4H3;1H/t14-,16+,17-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.{{Benzethonium} site|{Benzethonium} nAChR|{Benzethonium} Purity & Documentation|{Benzethonium} In stock|{Benzethonium} custom synthesis|{Benzethonium} Epigenetic Reader Domain} |Product information|CAS Number: 1008763-54-9|Molecular Weight: 409.95|Formula: C21H32ClN3O3|Chemical Name: 3-(2-aminoethyl)-5-methoxy-1-[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexanecarbonyl]-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride|Smiles: Cl.{{Sunvozertinib} site|{Sunvozertinib} EGFR|{Sunvozertinib} Biological Activity|{Sunvozertinib} References|{Sunvozertinib} manufacturer|{Sunvozertinib} Epigenetic Reader Domain} CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)N1C2=CC=C(C=C2N(CCN)C1=O)OC|InChiKey: DYMRNRVXSXCQHZ-UANXYBPYSA-N|InChi: InChI=1S/C21H31N3O3.PMID:24580853 ClH/c1-13(2)16-7-5-14(3)11-17(16)20(25)24-18-8-6-15(27-4)12-19(18)23(10-9-22)21(24)26;/h6,8,12-14,16-17H,5,7,9-11,22H2,1-4H3;1H/t14-,16+,17-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 140 mg/mL (341.51 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH.|Products are for research use only. Not for human use.|