Product Name :
AV-153
Description:
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity.
CAS:
27296-05-5
Molecular Weight:
319.29
Formula:
C14H18NNaO6
Chemical Name:
sodium 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate
Smiles :
[Na+].CC1NC(C)=C(C(C([O-])=O)C=1C(=O)OCC)C(=O)OCC
InChiKey:
DBROLRZEUAZZAL-UHFFFAOYSA-M
InChi :
InChI=1S/C14H19NO6.Na/c1-5-20-13(18)9-7(3)15-8(4)10(11(9)12(16)17)14(19)21-6-2;/h11,15H,5-6H2,1-4H3,(H,16,17);/q;+1/p-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity.|Product information|CAS Number: 27296-05-5|Molecular Weight: 319.29|Formula: C14H18NNaO6|Chemical Name: sodium 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate|Smiles: [Na+].CC1NC(C)=C(C(C([O-])=O)C=1C(=O)OCC)C(=O)OCC|InChiKey: DBROLRZEUAZZAL-UHFFFAOYSA-M|InChi: InChI=1S/C14H19NO6.Na/c1-5-20-13(18)9-7(3)15-8(4)10(11(9)12(16)17)14(19)21-6-2;/h11,15H,5-6H2,1-4H3,(H,16,17);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tirofiban} site|{Tirofiban} Integrin|{Tirofiban} Biological Activity|{Tirofiban} In Vivo|{Tirofiban} manufacturer|{Tirofiban} Autophagy} |Shelf Life: ≥12 months if stored properly.{{X-alpha-Gal} web|{X-alpha-Gal} {Biochemical Assay Reagents}|{X-alpha-Gal} Biological Activity|{X-alpha-Gal} Purity|{X-alpha-Gal} manufacturer|{X-alpha-Gal} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23829314 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AV-153 causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively. AV-153 (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13-67%.|Products are for research use only. Not for human use.|