AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: That is a representative sample of 20 current studies discovered on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures getting possible application for early illness detection. Research with fewer than 20 BC cases were excluded. Whilst these signatures mainly reflect greater amounts of circulating miRNAs, some miRNAs are detected at decrease levels in blood samples of BC sufferers. Blood collection was performed before surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the least 3 independent research. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable 2 miRNArelated risk loci related to BCGene locus MIR27A SNP rs895919 *C Comments Population IPI549 Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No risk association Protective dar.12324 improved threat Decreased threat No danger association Decreased risk Decreased risk Decreased danger No risk association No risk association elevated survival No danger association Decreased ITI214 biological activity overall danger enhanced threat elevated danger No threat association elevated all round risk Decreased threat of eR+ BC No risk association earlier age of onset No danger association No risk association No risk association No risk association Decreased danger (C allele) No risk association No threat association No danger association No danger association No threat association No danger association No threat association No risk association Decreased danger Decreased threat Survival of HeR2+ instances No risk association Decreased threat No threat association Decreased danger Decreased danger Decreased threat increased threat elevated danger No danger association No risk association No danger association No risk association Decreased risk of eR- BC No danger association improved survival increased risk of eR- BC No danger association No risk association elevated overall threat No risk association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Key transcript Major transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: This really is a representative sample of 20 recent research located on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures possessing potential application for early illness detection. Studies with fewer than 20 BC circumstances have been excluded. Whilst these signatures primarily reflect higher amounts of circulating miRNAs, some miRNAs are detected at decrease levels in blood samples of BC individuals. Blood collection was performed just before surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the least 3 independent studies. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable 2 miRNArelated danger loci associated with BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No danger association Protective dar.12324 elevated danger Decreased danger No threat association Decreased danger Decreased risk Decreased danger No risk association No threat association enhanced survival No danger association Decreased all round threat improved threat increased threat No threat association elevated overall threat Decreased risk of eR+ BC No danger association earlier age of onset No threat association No risk association No danger association No danger association Decreased danger (C allele) No threat association No threat association No threat association No danger association No threat association No threat association No risk association No threat association Reduced risk Reduced danger Survival of HeR2+ circumstances No threat association Decreased risk No risk association Decreased danger Decreased danger Decreased danger increased danger improved risk No danger association No danger association No risk association No threat association Decreased threat of eR- BC No threat association enhanced survival increased threat of eR- BC No danger association No threat association elevated general danger No threat association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Primary transcript Key transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.
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