| Common Name |
Tyrosyl-Methionine
| Description |
Tyrosyl-Methionine is a dipeptide composed of tyrosine and methionine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB29111 (Tyrosyl-Methionine)
| Synonyms |
| Value |
Source |
L-Tyrosyl-L-methionineHMDB
Tyr-metHMDB
Tyrosine methionine dipeptideHMDB
Tyrosine-methionine dipeptideHMDB
TyrosylmethionineHMDB
Y-m dipeptideHMDB
YM dipeptideHMDB
| Chemical Formlia |
C14H20N2O4S
| Average Molecliar Weight |
312.385
| Monoisotopic Molecliar Weight |
312.114377828
| IUPAC Name |
2-[2-amino-3-(4-hydroxyphenyl)propanamido]-4-(methylslifanyl)butanoic acid
| Traditional Name |
2-[2-amino-3-(4-hydroxyphenyl)propanamido]-4-(methylslifanyl)butanoic acid
| CAS Registry Number |
Not Available
| SMILES |
CSCCC(NC(=O)C(N)CC1=CC=C(O)C=C1)C(O)=O
| InChI Identifier |
InChI=1S/C14H20N2O4S/c1-21-7-6-12(14(19)20)16-13(18)11(15)8-9-2-4-10(17)5-3-9/h2-5,11-12,17H,6-8,15H2,1H3,(H,16,18)(H,19,20)
| InChI Key |
KYPMKDGKAYQCHO-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Tyrosine and derivatives
Phenylalanine and derivatives
Methionine and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Amphetamines and derivatives
Thia fatty acids
Hydroxy fatty acids
Aralkylamines
1-hydroxy-2-unsubstituted benzenoids
Fatty amides
Secondary carboxylic acid amides
Amino acids
Slifenyl compounds
Monocarboxylic acids and derivatives
Dialkylthioethers
Carboxylic acids
Carbonyl compounds
Hydrocarbon derivatives
Monoalkylamines
Organic oxides
Organopnictogen compounds
| Substituents |
Alpha-dipeptide
Tyrosine or derivatives
Phenylalanine or derivatives
Methionine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
Alpha-amino acid or derivatives
Amphetamine or derivatives
1-hydroxy-2-unsubstituted benzenoid
Hydroxy fatty acid
Phenol
Thia fatty acid
Aralkylamine
Benzenoid
Fatty amide
Fatty acyl
Monocyclic benzene moiety
Secondary carboxylic acid amide
Carboxamide group
Amino acid or derivatives
Amino acid
Slifenyl compound
Thioether
Monocarboxylic acid or derivatives
Carboxylic acid
Dialkylthioether
Organic nitrogen compound
Primary aliphatic amine
Organonitrogen compound
Organooxygen compound
Organoslifur compound
Primary amine
Carbonyl group
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Amine
Organic oxygen compound
Aromatic homomonocyclic compound
| Molecliar Framework |
Aromatic homomonocyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-1.38Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility0.24 mg/mLALOGPS
logP-0.56ALOGPS
logP-1.4ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)3.63ChemAxon
pKa (Strongest Basic)8.02ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area112.65 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity81.48 m3·mol-1ChemAxon
Polarizability32.66 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB29111
| Metagene Link |
HMDB29111
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: GSK2256098
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Zhang H, Zielonka J, Sikora A, Joseph J, Xu Y, Kalyanaraman B: The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism? Arch Biochem Biophys. 2009 Apr 15;484(2):134-45. doi: 10.1016/j.abb.2008.11.018. Epub 2008 Nov 24. [PubMed:19056332 ]
|
PMID: 7562537
