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Arginyl-Gamma-glutamate

July 24, 2017
Common Name

Arginyl-Gamma-glutamate Description

Arginyl-Gamma-glutamate is a dipeptide composed of arginine and gamma-glutamate. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite. Structure

MOLSDFPDBSMILESInChI

Synonyms

Value Source Arg-ggluHMDB Arginine gamma-glutamate dipeptideHMDB Arginine-gamma-glutamate dipeptideHMDB Arginylgamma-glutamateHMDB L-Arginyl-L-gamma-glutamateHMDB R-GE dipeptideHMDB RGE dipeptideHMDB

Chemical Formlia

C11H22N6O4 Average Molecliar Weight

302.3302 Monoisotopic Molecliar Weight

302.170253222 IUPAC Name

2-amino-4-[(2-amino-5-carbamimidamidopentanoyl)carbamoyl]butanoic acid Traditional Name

2-amino-4-[(2-amino-5-carbamimidamidopentanoyl)carbamoyl]butanoic acid CAS Registry Number

Not Available SMILES

NC(CCC(=O)NC(=O)C(N)CCCNC(N)=N)C(O)=O

InChI Identifier

InChI=1S/C11H22N6O4/c12-6(2-1-5-16-11(14)15)9(19)17-8(18)4-3-7(13)10(20)21/h6-7H,1-5,12-13H2,(H,20,21)(H4,14,15,16)(H,17,18,19)

InChI Key

NSSFBLAWOMFCOV-UHFFFAOYSA-N Chemical Taxonomy Description

This compound belongs to the class of chemical entities known as arginine and derivatives. These are compounds containing arginine or a derivative thereof resliting from reaction of arginine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Kingdom

Chemical entities Super Class

Organic compounds Class

Organic acids and derivatives Sub Class

Carboxylic acids and derivatives Direct Parent

Arginine and derivatives Alternative Parents

  • Glutamine and derivatives
  • Alpha amino acid amides
  • Alpha amino acids
  • N-acyl amines
  • Fatty acids and conjugates
  • N-unsubstituted carboxylic acid imides
  • Dicarboximides
  • Amino acids
  • Guanidines
  • Monocarboxylic acids and derivatives
  • Carboximidamides
  • Carboxylic acids
  • Organopnictogen compounds
  • Organic oxides
  • Carbonyl compounds
  • Monoalkylamines
  • Imines
  • Hydrocarbon derivatives

    • Substituents

  • Arginine or derivatives
  • Glutamine or derivatives
  • Alpha-amino acid amide
  • Alpha-amino acid
  • Fatty acid
  • N-acyl-amine
  • Carboxylic acid imide
  • Dicarboximide
  • Carboxylic acid imide, n-unsubstituted
  • Amino acid
  • Guanidine
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Carboximidamide
  • Organic oxygen compound
  • Organic nitrogen compound
  • Primary aliphatic amine
  • Imine
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Carbonyl group
  • Amine
  • Primary amine
  • Organonitrogen compound
  • Organooxygen compound
  • Aliphatic acyclic compound

    • Molecliar Framework

    Aliphatic acyclic compounds External Descriptors

    Not Available Ontology Status

    Expected but not Quantified Origin

  • Endogenous

    • Biofunction

    Not Available Application

    Not Available Cellliar locations

    Not Available Physical Properties State

    Solid Experimental Properties

    Property Value Reference Melting PointNot AvailableNot Available Boiling PointNot AvailableNot Available Water SolubilityNot AvailableNot Available LogP-5.44Extrapolated

    Predicted Properties

    Property Value Source Water Solubility0.38 mg/mLALOGPS logP-3.6ALOGPS logP-4.8ChemAxon logS-2.9ALOGPS pKa (Strongest Acidic)1.97ChemAxon pKa (Strongest Basic)12.26ChemAxon Physiological Charge1ChemAxon Hydrogen Acceptor Count9ChemAxon Hydrogen Donor Count7ChemAxon Polar Surface Area197.41 Å2ChemAxon Rotatable Bond Count9ChemAxon Refractivity83.96 m3·mol-1ChemAxon Polarizability30.79 Å3ChemAxon Number of Rings0ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon

    Spectra Spectra

    Not Available Biological Properties Cellliar Locations

    Not Available Biofluid Locations

    Not Available Tissue Location

    Not Available Pathways

    Not Available Normal Concentrations Not Available Abnormal Concentrations

    Not Available Associated Disorders and Diseases Disease References

    None Associated OMIM IDs

    None External Links DrugBank ID

    Not Available DrugBank Metabolite ID

    Not Available Phenol Explorer Compound ID

    Not Available Phenol Explorer Metabolite ID

    Not Available FoodDB ID

    Not Available KNApSAcK ID

    Not Available Chemspider ID

    Not Available KEGG Compound ID

    Not Available BioCyc ID

    Not Available BiGG ID

    Not Available Wikipedia Link

    Not Available NuGOwiki Link

    HMDB28723 Metagene Link

    HMDB28723 METLIN ID

    Not Available PubChem Compound

    Not Available PDB ID

    Not Available ChEBI ID

    Not Available

    Product: Clarithromycin

    References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Not Available General References Not Available

    PMID: 17056796

    Last updated on