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Methionyl-Lysine

July 21, 2017
Common Name

Methionyl-Lysine Description

Methionyl-Lysine is a dipeptide composed of methionine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite. Structure

MOLSDF3D-SDFPDBSMILESInChI View 3D Structure

Structure for HMDB28978 (Methionyl-Lysine)

Synonyms

Value Source L-Methionyl-L-lysineHMDB m-K DipeptideHMDB Met-lysHMDB Methionine lysine dipeptideHMDB Methionine-lysine dipeptideHMDB MethionyllysineHMDB MK DipeptideHMDB

Chemical Formlia

C11H23N3O3S Average Molecliar Weight

277.384 Monoisotopic Molecliar Weight

277.146012307 IUPAC Name

6-amino-2-[2-amino-4-(methylslifanyl)butanamido]hexanoic acid Traditional Name

6-amino-2-[2-amino-4-(methylslifanyl)butanamido]hexanoic acid CAS Registry Number

Not Available SMILES

CSCCC(N)C(=O)NC(CCCCN)C(O)=O

InChI Identifier

InChI=1S/C11H23N3O3S/c1-18-7-5-8(13)10(15)14-9(11(16)17)4-2-3-6-12/h8-9H,2-7,12-13H2,1H3,(H,14,15)(H,16,17)

InChI Key

IMTUWVJPCQPJEE-UHFFFAOYSA-N Chemical Taxonomy Description

This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Kingdom

Chemical entities Super Class

Organic compounds Class

Organic acids and derivatives Sub Class

Carboxylic acids and derivatives Direct Parent

Dipeptides Alternative Parents

  • Methionine and derivatives
  • N-acyl-alpha amino acids
  • Alpha amino acid amides
  • Medium-chain fatty acids
  • Amino fatty acids
  • N-acyl amines
  • Amino acids
  • Secondary carboxylic acid amides
  • Monocarboxylic acids and derivatives
  • Slifenyl compounds
  • Dialkylthioethers
  • Carboxylic acids
  • Organopnictogen compounds
  • Organic oxides
  • Monoalkylamines
  • Hydrocarbon derivatives
  • Carbonyl compounds

    • Substituents

  • Alpha-dipeptide
  • Methionine or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • Alpha-amino acid or derivatives
  • Medium-chain fatty acid
  • Amino fatty acid
  • Fatty acyl
  • Fatty acid
  • Fatty amide
  • N-acyl-amine
  • Amino acid or derivatives
  • Amino acid
  • Carboxamide group
  • Secondary carboxylic acid amide
  • Carboxylic acid
  • Dialkylthioether
  • Monocarboxylic acid or derivatives
  • Slifenyl compound
  • Thioether
  • Amine
  • Organic oxygen compound
  • Primary aliphatic amine
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organic oxide
  • Organopnictogen compound
  • Primary amine
  • Organonitrogen compound
  • Organooxygen compound
  • Organoslifur compound
  • Aliphatic acyclic compound

    • Molecliar Framework

    Aliphatic acyclic compounds External Descriptors

    Not Available Ontology Status

    Expected but not Quantified Origin

  • Endogenous

    • Biofunction

    Not Available Application

    Not Available Cellliar locations

    Not Available Physical Properties State

    Solid Experimental Properties

    Property Value Reference Melting PointNot AvailableNot Available Boiling PointNot AvailableNot Available Water SolubilityNot AvailableNot Available LogP-2.98Extrapolated

    Predicted Properties

    Property Value Source Water Solubility3.08 mg/mLALOGPS logP-2.3ALOGPS logP-3ChemAxon logS-1.9ALOGPS pKa (Strongest Acidic)3.88ChemAxon pKa (Strongest Basic)10.21ChemAxon Physiological Charge1ChemAxon Hydrogen Acceptor Count5ChemAxon Hydrogen Donor Count4ChemAxon Polar Surface Area118.44 Å2ChemAxon Rotatable Bond Count10ChemAxon Refractivity72.2 m3·mol-1ChemAxon Polarizability30.74 Å3ChemAxon Number of Rings0ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon

    Spectra Spectra

    Not Available Biological Properties Cellliar Locations

    Not Available Biofluid Locations

    Not Available Tissue Location

    Not Available Pathways

    Not Available Normal Concentrations Not Available Abnormal Concentrations

    Not Available Associated Disorders and Diseases Disease References

    None Associated OMIM IDs

    None External Links DrugBank ID

    Not Available DrugBank Metabolite ID

    Not Available Phenol Explorer Compound ID

    Not Available Phenol Explorer Metabolite ID

    Not Available FoodDB ID

    Not Available KNApSAcK ID

    Not Available Chemspider ID

    Not Available KEGG Compound ID

    Not Available BioCyc ID

    Not Available BiGG ID

    Not Available Wikipedia Link

    Not Available NuGOwiki Link

    HMDB28978 Metagene Link

    HMDB28978 METLIN ID

    Not Available PubChem Compound

    Not Available PDB ID

    Not Available ChEBI ID

    Not Available

    Product: PF-06840003

    References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Not Available General References
    1. Li XM, Trinh KY, Hew CL: Expression and characterization of an active and thermally more stable recombinant antifreeze polypeptide from ocean pout, Macrozoarces americanus, in Escherichia coli: improved expression by the modification of the secondary structure of the mRNA. Protein Eng. 1991 Dec;4(8):995-1002. [PubMed:1817264 ]
    2. McFadden RG, Vickers KE: Bradykinin augments the in vitro migration of nonsensitized lymphocytes. Clin Invest Med. 1989 Aug;12(4):247-53. [PubMed:2562502 ]
    3. Boric MP, Figueroa XF, Albertini R, Roblero JS: Croxattos fifty-year pursuit: from pepsanurin to the discovery of a new kininogen-derived peptide (PU-D1). Biol Res. 1998;31(3):117-29. [PubMed:9830498 ]

    PMID: 8692282

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