| Common Name |
Methionyl-Glutamate
| Description |
Methionyl-Glutamate is a dipeptide composed of methionine and glutamate. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDFPDBSMILESInChI
Structure for HMDB28972 (Methionyl-Glutamate)
| Synonyms |
| Value |
Source |
L-Methionyl-L-glutamateHMDB
m-e DipeptideHMDB
ME dipeptideHMDB
Met-gluHMDB
Methionine glutamate dipeptideHMDB
Methionine-glutamate dipeptideHMDB
MethionylglutamateHMDB
| Chemical Formlia |
C10H17N2O5S
| Average Molecliar Weight |
277.317
| Monoisotopic Molecliar Weight |
277.085817354
| IUPAC Name |
2-[2-amino-4-(methylslifanyl)butanamido]-4-carboxybutanoate
| Traditional Name |
2-[2-amino-4-(methylslifanyl)butanamido]-4-carboxybutanoate
| CAS Registry Number |
Not Available
| SMILES |
CSCCC(N)C(=O)NC(CCC(O)=O)C([O-])=O
| InChI Identifier |
InChI=1S/C10H18N2O5S/c1-18-5-4-6(11)9(15)12-7(10(16)17)2-3-8(13)14/h6-7H,2-5,11H2,1H3,(H,12,15)(H,13,14)(H,16,17)/p-1
| InChI Key |
ADHNYKZHPOEULM-UHFFFAOYSA-M
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Glutamic acid and derivatives
Methionine and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Dicarboxylic acids and derivatives
Fatty acids and conjugates
N-acyl amines
Secondary carboxylic acid amides
Amino acids
Slifenyl compounds
Carboxylic acids
Dialkylthioethers
Organic oxides
Carbonyl compounds
Organopnictogen compounds
Monoalkylamines
Hydrocarbon derivatives
Organic anions
| Substituents |
Alpha-dipeptide
Glutamic acid or derivatives
Methionine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
Alpha-amino acid or derivatives
Dicarboxylic acid or derivatives
Fatty amide
N-acyl-amine
Fatty acid
Fatty acyl
Amino acid
Secondary carboxylic acid amide
Amino acid or derivatives
Carboxamide group
Slifenyl compound
Thioether
Dialkylthioether
Carboxylic acid
Hydrocarbon derivative
Primary amine
Organic oxide
Organopnictogen compound
Organic oxygen compound
Primary aliphatic amine
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Carbonyl group
Organoslifur compound
Amine
Organic anion
Aliphatic acyclic compound
| Molecliar Framework |
Aliphatic acyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.37Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility5.13 mg/mLALOGPS
logP-2.3ALOGPS
logP-3.4ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)3.36ChemAxon
pKa (Strongest Basic)8.42ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area132.55 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity76.51 m3·mol-1ChemAxon
Polarizability27.7 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28972
| Metagene Link |
HMDB28972
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: SP-13786
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- de Leon MJ, Convit A, Wolf OT, Tarshish CY, DeSanti S, Rusinek H, Tsui W, Kandil E, Scherer AJ, Roche A, Imossi A, Thorn E, Bobinski M, Caraos C, Lesbre P, Schlyer D, Poirier J, Reisberg B, Fowler J: Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET). Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10966-71. Epub 2001 Aug 28. [PubMed:11526211 ]
- Mosconi L, Sorbi S, Nacmias B, De Cristofaro MT, Fayyaz M, Cellini E, Bagnoli S, Bracco L, Herholz K, Pupi A: Brain metabolic differences between sporadic and familial Alzheimers disease. Neurology. 2003 Oct 28;61(8):1138-40. [PubMed:14581683 ]
|
PMID: 9652357
