| Common Name |
Histidinyl-Tyrosine
| Description |
Histidinyl-Tyrosine is a dipeptide composed of histidine and tyrosine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB28897 (Histidinyl-Tyrosine)
| Synonyms |
| Value |
Source |
H-Y dipeptideHMDB
His-tyrHMDB
Histidine tyrosine dipeptideHMDB
Histidine-tyrosine dipeptideHMDB
HistidinyltyrosineHMDB
HY dipeptideHMDB
L-Histidinyl-L-tyrosineHMDB
| Chemical Formlia |
C15H18N4O4
| Average Molecliar Weight |
318.3278
| Monoisotopic Molecliar Weight |
318.132805084
| IUPAC Name |
2-[2-amino-3-(1H-imidazol-5-yl)propanamido]-3-(4-hydroxyphenyl)propanoic acid
| Traditional Name |
2-[2-amino-3-(3H-imidazol-4-yl)propanamido]-3-(4-hydroxyphenyl)propanoic acid
| CAS Registry Number |
Not Available
| SMILES |
NC(CC1=CN=CN1)C(=O)NC(CC1=CC=C(O)C=C1)C(O)=O
| InChI Identifier |
InChI=1S/C15H18N4O4/c16-12(6-10-7-17-8-18-10)14(21)19-13(15(22)23)5-9-1-3-11(20)4-2-9/h1-4,7-8,12-13,20H,5-6,16H2,(H,17,18)(H,19,21)(H,22,23)
| InChI Key |
HTOOKGDPMXSJSY-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Tyrosine and derivatives
Phenylalanine and derivatives
Histidine and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Phenylpropanoic acids
Amphetamines and derivatives
Imidazolyl carboxylic acids and derivatives
Aralkylamines
1-hydroxy-2-unsubstituted benzenoids
Fatty amides
Heteroaromatic compounds
Secondary carboxylic acid amides
Amino acids
Azacyclic compounds
Monocarboxylic acids and derivatives
Carboxylic acids
Carbonyl compounds
Hydrocarbon derivatives
Monoalkylamines
Organic oxides
Organopnictogen compounds
| Substituents |
Alpha-dipeptide
Tyrosine or derivatives
Phenylalanine or derivatives
Histidine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
3-phenylpropanoic-acid
Alpha-amino acid or derivatives
Amphetamine or derivatives
Imidazolyl carboxylic acid derivative
1-hydroxy-2-unsubstituted benzenoid
Phenol
Aralkylamine
Monocyclic benzene moiety
Fatty amide
Benzenoid
Fatty acyl
Heteroaromatic compound
Azole
Imidazole
Amino acid
Amino acid or derivatives
Secondary carboxylic acid amide
Carboxamide group
Azacycle
Organoheterocyclic compound
Carboxylic acid
Monocarboxylic acid or derivatives
Primary amine
Amine
Organic oxygen compound
Carbonyl group
Organic nitrogen compound
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organopnictogen compound
Aromatic heteromonocyclic compound
| Molecliar Framework |
Aromatic heteromonocyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-2.62Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility1.14 mg/mLALOGPS
logP-1.7ALOGPS
logP-2.6ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)3.3ChemAxon
pKa (Strongest Basic)8.01ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area141.33 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity81.96 m3·mol-1ChemAxon
Polarizability32.18 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28897
| Metagene Link |
HMDB28897
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: TD139
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Wang DX, Wang N, Lu GC, Xu QC, Wang NG, Guan MZ: [Synthesis of tyrosine-related peptide and their effect on progesterone production]. Yao Xue Xue Bao. 1994;29(6):438-42. [PubMed:7992624 ]
- Scholten JD, Zimmerman KK, Oxender MG, Leonard D, Sebolt-Leopold J, Gowan R, Hupe DJ: Synergy between anions and farnesyldiphosphate competitive inhibitors of farnesyl:protein transferase. J Biol Chem. 1997 Jul 18;272(29):18077-81. [PubMed:9218438 ]
|
PMID: 17075569
