| Common Name |
Cysteinyl-Glutamate
| Description |
Cysteinyl-Glutamate is a dipeptide composed of cysteine and glutamate. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDFPDBSMILESInChI
Structure for HMDB28774 (Cysteinyl-Glutamate)
| Synonyms |
| Value |
Source |
C-e DipeptideHMDB
CE dipeptideHMDB
Cys-gluHMDB
Cysteine glutamate dipeptideHMDB
Cysteine-glutamate dipeptideHMDB
CysteinylglutamateHMDB
L-Cysteinyl-L-glutamateHMDB
| Chemical Formlia |
C8H13N2O5S
| Average Molecliar Weight |
249.264
| Monoisotopic Molecliar Weight |
249.054517226
| IUPAC Name |
2-(2-amino-3-slifanylpropanamido)-4-carboxybutanoate
| Traditional Name |
2-(2-amino-3-slifanylpropanamido)-4-carboxybutanoate
| CAS Registry Number |
Not Available
| SMILES |
NC(CS)C(=O)NC(CCC(O)=O)C([O-])=O
| InChI Identifier |
InChI=1S/C8H14N2O5S/c9-4(3-16)7(13)10-5(8(14)15)1-2-6(11)12/h4-5,16H,1-3,9H2,(H,10,13)(H,11,12)(H,14,15)/p-1
| InChI Key |
BUXAPSQPMALTOY-UHFFFAOYSA-M
| Chemical Taxonomy |
| Classification |
Not classified
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.98Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility6.03 mg/mLALOGPS
logP-2.7ALOGPS
logP-4ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)3.25ChemAxon
pKa (Strongest Basic)8.07ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area132.55 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity67.15 m3·mol-1ChemAxon
Polarizability23.36 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28774
| Metagene Link |
HMDB28774
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: PDE1-IN-2
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Abreu IA, Xavier AV, LeGall J, Cabelli DE, Teixeira M: Superoxide scavenging by neelaredoxin: dismutation and reduction activities in anaerobes. J Biol Inorg Chem. 2002 Jun;7(6):668-74. Epub 2002 Apr 18. [PubMed:12072976 ]
- Mutlib AE, Dickenson P, Chen SY, Espina RJ, Daniels JS, Gan LS: Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates. Chem Res Toxicol. 2002 Sep;15(9):1190-207. [PubMed:12230413 ]
|
PMID: 8755606
