Product Name :
PTACH
Description:
PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 µM) .
CAS:
848354-66-5
Molecular Weight:
390.56
Formula:
C20H26N2O2S2
Chemical Name:
7-[(2-methylpropanoyl)sulfanyl]-N-(4-phenyl-1,3-thiazol-2-yl)heptanamide
Smiles :
CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C1C=CC=CC=1
InChiKey:
MDYDGUOQFUQOGE-UHFFFAOYSA-N
InChi :
InChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 µM) .|Product information|CAS Number: 848354-66-5|Molecular Weight: 390.56|Formula: C20H26N2O2S2|Chemical Name: 7-[(2-methylpropanoyl)sulfanyl]-N-(4-phenyl-1,3-thiazol-2-yl)heptanamide|Smiles: CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C1C=CC=CC=1|InChiKey: MDYDGUOQFUQOGE-UHFFFAOYSA-N|InChi: InChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (128.02 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Ceftaroline fosamil Purity & Documentation |Shelf Life: ≥12 months if stored properly.Carotuximab Immunology/Inflammation |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32427504 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21WAF1/CIP1 in a dose-dependent manner. In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively. PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter.|Products are for research use only. Not for human use.|