Product Name :
INH6
Description:
INH6 is a potent Nek2/Hec1 inhibitor; inhibits the growth of HeLa cells with an IC50 of 2.4 μM.
CAS:
1001753-24-7
Molecular Weight:
322.42
Formula:
C19H18N2OS
Chemical Name:
N-[4-(2, 4, 6-trimethylphenyl)-1, 3-thiazol-2-yl]benzamide
Smiles :
CC1C=C(C)C=C(C)C=1C1=CSC(NC(=O)C2C=CC=CC=2)=N1
InChiKey:
WCZLNJTXHZPHLM-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18N2OS/c1-12-9-13(2)17(14(3)10-12)16-11-23-19(20-16)21-18(22)15-7-5-4-6-8-15/h4-11H,1-3H3,(H,20,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
INH6 is a potent Nek2/Hec1 inhibitor; inhibits the growth of HeLa cells with an IC50 of 2.4 μM.|Product information|CAS Number: 1001753-24-7|Molecular Weight: 322.42|Formula: C19H18N2OS|Chemical Name: N-[4-(2, 4, 6-trimethylphenyl)-1, 3-thiazol-2-yl]benzamide|Smiles: CC1C=C(C)C=C(C)C=1C1=CSC(NC(=O)C2C=CC=CC=2)=N1|InChiKey: WCZLNJTXHZPHLM-UHFFFAOYSA-N|InChi: InChI=1S/C19H18N2OS/c1-12-9-13(2)17(14(3)10-12)16-11-23-19(20-16)21-18(22)15-7-5-4-6-8-15/h4-11H,1-3H3,(H,20,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (155.CPDA Purity 08 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Hec1 is an oncogene overly expressed in many human cancers. Small molecule INH (Inhibitor of Nek2/Hec1) targeting the Hec1 and its regulator, Nek2, in the mitotic pathway is identified to inactivate Hec1/Nek2 function mediated by protein degradation that subsequently leads to chromosome mis-segregation and cell death.1-(4-Methoxyphenyl)piperazine Drug Derivative INH6 treated cells exhibit increased mitotic population with multipolar spindle configurations.PMID:32602391 An increased rate of chromosome misalignment is detected upon treatment with INH6 of HeLa cells expressing the chromosome marker protein H2B-GFP. INH6 treated cells shows progressive morphological changes characteristic of dying cells (e.g., membrane bubbling), which is further confirmed by cell cycle profiling with FACS analysis. Approximately 20% of INH6 treated cells are apoptotic 72 hrs after treatment.|References:|Qiu XL, et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009 Mar 26;52(6):1757-67.Products are for research use only. Not for human use.|