Product Name :
L-SelenoMethionine
Description:
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase.
CAS:
3211-76-5
Molecular Weight:
196.11
Formula:
C5H11NO2Se
Chemical Name:
(2S)-2-amino-4-(methylselanyl)butanoic acid
Smiles :
C[Se]CC[C@H](N)C(O)=O
InChiKey:
RJFAYQIBOAGBLC-BYPYZUCNSA-N
InChi :
InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Olverembatinib} site|{Olverembatinib} Bcr-Abl|{Olverembatinib} Protocol|{Olverembatinib} Description|{Olverembatinib} manufacturer|{Olverembatinib} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells.{{Renilla-Firefly Luciferase Dual Assay Kit} MedChemExpress|{Renilla-Firefly Luciferase Dual Assay Kit} Immunology/Inflammation|{Renilla-Firefly Luciferase Dual Assay Kit} Technical Information|{Renilla-Firefly Luciferase Dual Assay Kit} In stock|{Renilla-Firefly Luciferase Dual Assay Kit} custom synthesis} L-SelenoMethionine also can increase expression of glutathione peroxidase.|Product information|CAS Number: 3211-76-5|Molecular Weight: 196.11|Formula: C5H11NO2Se|Chemical Name: (2S)-2-amino-4-(methylselanyl)butanoic acid|Smiles: C[Se]CC[C@H](N)C(O)=O|InChiKey: RJFAYQIBOAGBLC-BYPYZUCNSA-N|InChi: InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 14.29 mg/mL (72.87 mM; Need ultrasonic) DMSO : 1 mg/mL (5.10 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells. L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells.PMID:31837211 L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells. L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation.|In Vivo:|L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.|References:|Schrauzer GN, et, al. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6.Menter DG, et, al. Selenium effects on prostate cell growth. Cancer Epidemiol Biomarkers Prev. 2000 Nov;9(11):1171-82.Jornot L, et, al. Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cells. Biochem J. 1995 Mar 1;306 ( Pt 2)(Pt 2):581-7.Nuth M, et, al. Mitigating effects of L-selenomethionine on low-dose iron ion radiation-induced changes in gene expression associated with cellular stress. Oncol Lett. 2013 Jul;6(1):35-42.Products are for research use only. Not for human use.|