ABT-418 hydrochloride

Product Name :
ABT-418 hydrochloride

Description:
ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer’s disease.

CAS:
147388-83-8

Molecular Weight:
202.68

Formula:
C9H15ClN2O

Chemical Name:
3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole hydrochloride

Smiles :
Cl.CC1C=C(ON=1)[C@@H]1CCCN1C

InChiKey:
VOXHERKWAIEJQF-QRPNPIFTSA-N

InChi :
InChI=1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer’s disease.|Product information|CAS Number: 147388-83-8|Molecular Weight: 202.68|Formula: C9H15ClN2O|Chemical Name: 3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole hydrochloride|Smiles: Cl.{{Hydrocortisone} MedChemExpress|{Hydrocortisone} Glucocorticoid Receptor|{Hydrocortisone} Protocol|{Hydrocortisone} References|{Hydrocortisone} custom synthesis|{Hydrocortisone} Cancer} CC1C=C(ON=1)[C@@H]1CCCN1C|InChiKey: VOXHERKWAIEJQF-QRPNPIFTSA-N|InChi: InChI=1S/C9H14N2O.{{GS-441524} site|{GS-441524} Anti-infection|{GS-441524} Biological Activity|{GS-441524} In stock|{GS-441524} custom synthesis|{GS-441524} Epigenetic Reader Domain} ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0.PMID:32493000 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 11.9 mg/mL (58.71 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze. Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment. ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD. ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.|Products are for research use only. Not for human use.|

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