Product Name :
Tos-PEG2-O-Propargyl
Description:
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458).
CAS:
1119249-30-7
Molecular Weight:
298.35
Formula:
C14H18O5S
Chemical Name:
2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate
Smiles :
CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCC#C
InChiKey:
XOLBARIQCXNLPS-UHFFFAOYSA-N
InChi :
InChI=1S/C14H18O5S/c1-3-8-17-9-10-18-11-12-19-20(15,16)14-6-4-13(2)5-7-14/h1,4-7H,8-12H2,2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.{{[Leu5]-Enkephalin} site|{[Leu5]-Enkephalin} GPCR/G Protein|{[Leu5]-Enkephalin} Purity & Documentation|{[Leu5]-Enkephalin} Data Sheet|{[Leu5]-Enkephalin} supplier|{[Leu5]-Enkephalin} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Biocytin} medchemexpress|{Biocytin} Endogenous Metabolite|{Biocytin} Immunology/Inflammation|{Biocytin} Technical Information|{Biocytin} Formula|{Biocytin} manufacturer}
Additional information:
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458).|Product information|CAS Number: 1119249-30-7|Molecular Weight: 298.35|Formula: C14H18O5S|Chemical Name: 2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate|Smiles: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCC#C|InChiKey: XOLBARIQCXNLPS-UHFFFAOYSA-N|InChi: InChI=1S/C14H18O5S/c1-3-8-17-9-10-18-11-12-19-20(15,16)14-6-4-13(2)5-7-14/h1,4-7H,8-12H2,2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Ethanol : 50 mg/mL (167.59 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32589561 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.Products are for research use only. Not for human use.|