Product Name :
Ceritinib (LDK378)
CAS No.:
1032900-25-6
Purity :
> 97%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
CC(C)OC1=C(NC2=NC(=C(Cl)C=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4
Product Description :
Ceritinib (LDK378) is potent inhibitor against ALK with IC50 of 0.{{581-05-5} medchemexpress|{581-05-5} Technical Information|{581-05-5} In Vitro|{581-05-5} custom synthesis} 2 nM in cell-free assays, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.{{2081072-29-7} web|{2081072-29-7} Protocol|{2081072-29-7} In Vitro|{2081072-29-7} custom synthesis} Phase 3.PMID:29083799
Formula:
C28H36ClN5O3S
Molecular Weight :
558.14
Synonyms:
Additional Information:
|CAS No. 1032900-25-6 ; |Formula C28H36ClN5O3S ; |Molecular Weight 558.14 ; |SMILES CC(C)OC1=C(NC2=NC(=C(Cl)C=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4 ; |Product Description Ceritinib (LDK378) is potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Phase 3. ; |Purity > 97% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO