Product Name :
SX-682
Description:
SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.
CAS:
1648843-04-2
Molecular Weight:
467.20
Formula:
C19H14BF4N3O4S
Chemical Name:
{2-[({5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl}sulfanyl)methyl]-4-(trifluoromethoxy)phenyl}boronic acid
Smiles :
OB(O)C1=CC=C(C=C1CSC1N=CC(=CN=1)C(=O)NC1=CC=C(F)C=C1)OC(F)(F)F
InChiKey:
SDUDZBCEHIZMFZ-UHFFFAOYSA-N
InChi :
InChI=1S/C19H14BF4N3O4S/c21-13-1-3-14(4-2-13)27-17(28)12-8-25-18(26-9-12)32-10-11-7-15(31-19(22,23)24)5-6-16(11)20(29)30/h1-9,29-30H,10H2,(H,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nefazodone} MedChemExpress|{Nefazodone} GPCR/G Protein|{Nefazodone} Technical Information|{Nefazodone} Data Sheet|{Nefazodone} supplier|{Nefazodone} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Gossypol} medchemexpress|{Gossypol} Bcl-2 Family|{Gossypol} Technical Information|{Gossypol} Description|{Gossypol} custom synthesis|{Gossypol} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23892407
Additional information:
SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.|Product information|CAS Number: 1648843-04-2|Molecular Weight: 467.20|Formula: C19H14BF4N3O4S|Chemical Name: {2-[({5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl}sulfanyl)methyl]-4-(trifluoromethoxy)phenyl}boronic acid|Smiles: OB(O)C1=CC=C(C=C1CSC1N=CC(=CN=1)C(=O)NC1=CC=C(F)C=C1)OC(F)(F)F|InChiKey: SDUDZBCEHIZMFZ-UHFFFAOYSA-N|InChi: InChI=1S/C19H14BF4N3O4S/c21-13-1-3-14(4-2-13)27-17(28)12-8-25-18(26-9-12)32-10-11-7-15(31-19(22,23)24)5-6-16(11)20(29)30/h1-9,29-30H,10H2,(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (535.10 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|SX-682 (50 mg/kg; orally; twice a day on a Monday through Friday) has Meager to moderate effects as single agents on CRPC progression was observed, yet combination with ICB produced strong efficacy.|Products are for research use only. Not for human use.|