Product Name :
A-286982
Description:
A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively.
CAS:
280749-17-9
Molecular Weight:
453.55
Formula:
C24H27N3O4S
Chemical Name:
(2E)-1-(4-acetylpiperazin-1-yl)-3-(3-nitro-4-{[2-(propan-2-yl)phenyl]sulfanyl}phenyl)prop-2-en-1-one
Smiles :
CC(=O)N1CCN(CC1)C(=O)/C=C/C1=CC(=C(C=C1)SC1=CC=CC=C1C(C)C)[N+]([O-])=O
InChiKey:
HTGGAYLWTDOFDK-PKNBQFBNSA-N
InChi :
InChI=1S/C24H27N3O4S/c1-17(2)20-6-4-5-7-22(20)32-23-10-8-19(16-21(23)27(30)31)9-11-24(29)26-14-12-25(13-15-26)18(3)28/h4-11,16-17H,12-15H2,1-3H3/b11-9+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively.|Product information|CAS Number: 280749-17-9|Molecular Weight: 453.55|Formula: C24H27N3O4S|Chemical Name: (2E)-1-(4-acetylpiperazin-1-yl)-3-(3-nitro-4-{[2-(propan-2-yl)phenyl]sulfanyl}phenyl)prop-2-en-1-one|Smiles: CC(=O)N1CCN(CC1)C(=O)/C=C/C1=CC(=C(C=C1)SC1=CC=CC=C1C(C)C)[N+]([O-])=O|InChiKey: HTGGAYLWTDOFDK-PKNBQFBNSA-N|InChi: InChI=1S/C24H27N3O4S/c1-17(2)20-6-4-5-7-22(20)32-23-10-8-19(16-21(23)27(30)31)9-11-24(29)26-14-12-25(13-15-26)18(3)28/h4-11,16-17H,12-15H2,1-3H3/b11-9+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ryanodine} medchemexpress|{Ryanodine} Technical Information|{Ryanodine} Purity|{Ryanodine} supplier|{Ryanodine} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Fremanezumab} web|{Fremanezumab} Neuronal Signaling|{Fremanezumab} Protocol|{Fremanezumab} Data Sheet|{Fremanezumab} manufacturer|{Fremanezumab} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35991869 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site.|Products are for research use only. Not for human use.|