Product Name :
WS 383
Description:
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
CAS:
2247544-02-9
Molecular Weight:
498.46
Formula:
C18H21Cl2N9S2
Chemical Name:
(2-{5-[(2-{[(4-chlorophenyl)methyl]sulfanyl}-5-methyl-[1, 2, 4]triazolo[1, 5-a]pyrimidin-7-yl)sulfanyl]-1H-1, 2, 3, 4-tetrazol-1-yl}ethyl)dimethylamine hydrochloride
Smiles :
Cl.CN(C)CCN1N=NN=C1SC1=CC(C)=NC2=NC(=NN21)SCC1=CC=C(Cl)C=C1
InChiKey:
LJZUAAKUJAXXHQ-UHFFFAOYSA-N
InChi :
InChI=1S/C18H20ClN9S2.ClH/c1-12-10-15(30-18-22-24-25-27(18)9-8-26(2)3)28-16(20-12)21-17(23-28)29-11-13-4-6-14(19)7-5-13;/h4-7,10H,8-9,11H2,1-3H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Etokimab} web|{Etokimab} Interleukin Related|{Etokimab} Biological Activity|{Etokimab} Data Sheet|{Etokimab} custom synthesis|{Etokimab} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).{{Linzagolix} medchemexpress|{Linzagolix} GnRH Receptor|{Linzagolix} Technical Information|{Linzagolix} Data Sheet|{Linzagolix} manufacturer|{Linzagolix} Cancer} |Product information|CAS Number: 2247544-02-9|Molecular Weight: 498.PMID:23439434 46|Formula: C18H21Cl2N9S2|Synonym:|WS-383|WS383|Chemical Name: (2-{5-[(2-{[(4-chlorophenyl)methyl]sulfanyl}-5-methyl-[1, 2, 4]triazolo[1, 5-a]pyrimidin-7-yl)sulfanyl]-1H-1, 2, 3, 4-tetrazol-1-yl}ethyl)dimethylamine hydrochloride|Smiles: Cl.CN(C)CCN1N=NN=C1SC1=CC(C)=NC2=NC(=NN21)SCC1=CC=C(Cl)C=C1|InChiKey: LJZUAAKUJAXXHQ-UHFFFAOYSA-N|InChi: InChI=1S/C18H20ClN9S2.ClH/c1-12-10-15(30-18-22-24-25-27(18)9-8-26(2)3)28-16(20-12)21-17(23-28)29-11-13-4-6-14(19)7-5-13;/h4-7,10H,8-9,11H2,1-3H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 7.35 mg/mL (14.75 mM), Need ultrasonic|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|WS-383 (10 μM) is selective to the DCN1–UBC12 interaction over the selected kinasesr. WS-383 (0.03-3 μM;24 hours) blocks Cul3 neddylation at 3 μM and also has certain inhibition of Cul1 neddylation at 10 μM but was not effective in inhibiting neddylation of other cullin members. WS-383 (0.03-3 μM;24 hours) increases Cul1, Skp1 (adaptor protein), F-box protein, and RBX1/RBX2 RING protein form SCF E3 complex. Cyclin dependent kinase inhibitor 1A (p21) and cyclin dependent kinase inhibitor 1B (p27) expression in a dose-dependent manner in MGC-803 and KYSE70 manner.|References:|Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2019 Mar 14;62(5):2772-2797.Products are for research use only. Not for human use.|