Product Name :
MSN-50
Description:
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
CAS:
1592908-75-2
Molecular Weight:
688.61
Formula:
C36H38BrN3O6
Chemical Name:
(2S)-N-{[(2R,3S)-3-amino-6-[(2-methoxyethoxy)methoxy]-2,3-dihydro-1-benzofuran-2-yl]methyl}-N-[(4-bromophenyl)methyl]-3-phenyl-2-(phenylformamido)propanamide
Smiles :
COCCOCOC1=CC2O[C@H](CN(CC3C=CC(Br)=CC=3)C(=O)[C@H](CC3C=CC=CC=3)NC(=O)C3C=CC=CC=3)[C@@H](N)C=2C=C1
InChiKey:
QRQAGDGLLUPMLV-IGOOQNSHSA-N
InChi :
InChI=1S/C36H38BrN3O6/c1-43-18-19-44-24-45-29-16-17-30-32(21-29)46-33(34(30)38)23-40(22-26-12-14-28(37)15-13-26)36(42)31(20-25-8-4-2-5-9-25)39-35(41)27-10-6-3-7-11-27/h2-17,21,31,33-34H,18-20,22-24,38H2,1H3,(H,39,41)/t31-,33+,34-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MSN-50 is a Bax and Bak oligomerization inhibitor.{{Tedizolid} MedChemExpress|{Tedizolid} Antibiotic|{Tedizolid} Technical Information|{Tedizolid} Purity|{Tedizolid} manufacturer|{Tedizolid} Autophagy} MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.{{Omidenepag isopropyl} web|{Omidenepag isopropyl} Prostaglandin Receptor|{Omidenepag isopropyl} Technical Information|{Omidenepag isopropyl} References|{Omidenepag isopropyl} supplier|{Omidenepag isopropyl} Autophagy} |Product information|CAS Number: 1592908-75-2|Molecular Weight: 688.PMID:32180353 61|Formula: C36H38BrN3O6|Chemical Name: (2S)-N-{[(2R,3S)-3-amino-6-[(2-methoxyethoxy)methoxy]-2,3-dihydro-1-benzofuran-2-yl]methyl}-N-[(4-bromophenyl)methyl]-3-phenyl-2-(phenylformamido)propanamide|Smiles: COCCOCOC1=CC2O[C@H](CN(CC3C=CC(Br)=CC=3)C(=O)[C@H](CC3C=CC=CC=3)NC(=O)C3C=CC=CC=3)[C@@H](N)C=2C=C1|InChiKey: QRQAGDGLLUPMLV-IGOOQNSHSA-N|InChi: InChI=1S/C36H38BrN3O6/c1-43-18-19-44-24-45-29-16-17-30-32(21-29)46-33(34(30)38)23-40(22-26-12-14-28(37)15-13-26)36(42)31(20-25-8-4-2-5-9-25)39-35(41)27-10-6-3-7-11-27/h2-17,21,31,33-34H,18-20,22-24,38H2,1H3,(H,39,41)/t31-,33+,34-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MSN-50 (0~10 uM) inhibits dye release from liposomes in a concentration-dependent fashion. MSN-50 (0~40 uM) inhibits tBid/Bax-mediated MOMP (mitochondrial outer membrane permeabilization) in a concentration-dependent manner and shows concentration-dependent inhibition of Bak-mediated MOMP. MSN-50 inhibits both Bax and Bak after activation by either cBid or Bim. MSN-50 (5 μM; BMK cells) inhibits apoptosis induced by actinomycin D and staurosporin (STS).|Products are for research use only. Not for human use.|