Product Name :
PF-00835231
Description:
PF-00835231 is a 3CLpro (Mpro) inhibitor that may targets SARS-CoV-2 protease 3CLpro.
CAS:
870153-29-0
Molecular Weight:
472.53
Formula:
C24H32N4O6
Chemical Name:
N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide
Smiles :
CC(C)C[C@H](NC(=O)C1=CC2C(=CC=CC=2OC)N1)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)CO
InChiKey:
QDIMHKWNHMVDJB-WBAXXEDZSA-N
InChi :
InChI=1S/C24H32N4O6/c1-13(2)9-18(23(32)27-17(20(30)12-29)10-14-7-8-25-22(14)31)28-24(33)19-11-15-16(26-19)5-4-6-21(15)34-3/h4-6,11,13-14,17-18,26,29H,7-10,12H2,1-3H3,(H,25,31)(H,27,32)(H,28,33)/t14-,17-,18-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{PhIP} MedChemExpress|{PhIP} Technical Information|{PhIP} In stock|{PhIP} custom synthesis|{PhIP} Cancer}
Shelf Life:
≥12 months if stored properly.{{Baclofen} MedChemExpress|{Baclofen} GABA Receptor|{Baclofen} Purity & Documentation|{Baclofen} Data Sheet|{Baclofen} custom synthesis|{Baclofen} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-00835231 is a 3CLpro (Mpro) inhibitor that may targets SARS-CoV-2 protease 3CLpro.|Product information|CAS Number: 870153-29-0|Molecular Weight: 472.PMID:24179643 53|Formula: C24H32N4O6|Chemical Name: N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide|Smiles: CC(C)C[C@H](NC(=O)C1=CC2C(=CC=CC=2OC)N1)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)CO|InChiKey: QDIMHKWNHMVDJB-WBAXXEDZSA-N|InChi: InChI=1S/C24H32N4O6/c1-13(2)9-18(23(32)27-17(20(30)12-29)10-14-7-8-25-22(14)31)28-24(33)19-11-15-16(26-19)5-4-6-21(15)34-3/h4-6,11,13-14,17-18,26,29H,7-10,12H2,1-3H3,(H,25,31)(H,27,32)(H,28,33)/t14-,17-,18-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO 95 mg/mL (201.05 mM) Ethanol 95 mg/mL (201.05 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|A time-of-drug-addition approach delineates the timing of early SARS-CoV-2 life cycle steps in A549+ACE2 cells and validates PF-00835231’s early time of action. In a model of the human polarized airway epithelium, PF-00835231 potently inhibits SARS-CoV-2 at low micromolar concentrations. PF-00835231 exhibits the potential as an effective SARS-CoV-2 antiviral.|References:|Maren de Vries, et al. J Virol. 2021 Feb 23;JVI.01819-20.Products are for research use only. Not for human use.|