Product Name :
COH-SR4
Description:
COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders.
CAS:
73439-19-7
Molecular Weight:
350.03
Formula:
C13H8Cl4N2O
Chemical Name:
1,3-bis(3,5-dichlorophenyl)urea
Smiles :
O=C(NC1=CC(Cl)=CC(Cl)=C1)NC1=CC(Cl)=CC(Cl)=C1
InChiKey:
VKVJIWVUYNTBEZ-UHFFFAOYSA-N
InChi :
InChI=1S/C13H8Cl4N2O/c14-7-1-8(15)4-11(3-7)18-13(20)19-12-5-9(16)2-10(17)6-12/h1-6H,(H2,18,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ligelizumab} MedChemExpress|{Ligelizumab} Protocol|{Ligelizumab} In Vitro|{Ligelizumab} custom synthesis|{Ligelizumab} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Atacicept} web|{Atacicept} Purity & Documentation|{Atacicept} In Vivo|{Atacicept} supplier|{Atacicept} Epigenetic Reader Domain}
Additional information:
COH-SR4 is an AMPK activator.PMID:23398362 COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders.|Product information|CAS Number: 73439-19-7|Molecular Weight: 350.03|Formula: C13H8Cl4N2O|Chemical Name: 1,3-bis(3,5-dichlorophenyl)urea|Smiles: O=C(NC1=CC(Cl)=CC(Cl)=C1)NC1=CC(Cl)=CC(Cl)=C1|InChiKey: VKVJIWVUYNTBEZ-UHFFFAOYSA-N|InChi: InChI=1S/C13H8Cl4N2O/c14-7-1-8(15)4-11(3-7)18-13(20)19-12-5-9(16)2-10(17)6-12/h1-6H,(H2,18,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (357.11 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|COH-SR4 (1-5 μM; 24 hours) results in a dose-dependent increase in the phosphorylation of AMPK and its substrate ACC in 3T3-L1 preadipocytes, as well as in cancer cells such as HL-60, HeLa, MCF-7. COH-SR4 (3-5 µM; 7 days) significantly inhibits 3T3-L1 adipocyte differentiation in a dose-dependent manner. COH-SR4 (1-5 μM; 24 hours) promotes cell G1 cycle arrest. COH-SR4 significantly reduces intracellular lipid accumulation and downregulates the expression of key adipogenesis-related transcription factors and lipogenic proteins.|In Vivo:|COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake. COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice. COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice. COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice.|Products are for research use only. Not for human use.|