Product Name :
WIN54954
Description:
WIN54954 is a broad-spectrum antipicornavirus drug. WIN 54 954 is a potent antiviral agent with a highly significant effect on survival in CBV-induced myocarditis in the A/J mouse if treatment is started early. WIN 54954 effectively reduces virus replication and islet histologic changes acutely and decreases, at 7 weeks, both the metabolic alteration associated with diabetes mellitus and the incidence of detectable viral RNA in the pancreas.
CAS:
107355-45-3
Molecular Weight:
383.27
Formula:
C18H20Cl2N2O3
Chemical Name:
Isoxazole, 5-(5-(2, 6-dichloro-4-(4, 5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methyl-
Smiles :
CC1C=C(CCCCCOC2C(Cl)=CC(=CC=2Cl)C2=NCCO2)ON=1
InChiKey:
JJDHAOLOHQTGMG-UHFFFAOYSA-N
InChi :
InChI=1S/C18H20Cl2N2O3/c1-12-9-14(25-22-12)5-3-2-4-7-23-17-15(19)10-13(11-16(17)20)18-21-6-8-24-18/h9-11H,2-8H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
WIN54954 is a broad-spectrum antipicornavirus drug. WIN 54 954 is a potent antiviral agent with a highly significant effect on survival in CBV-induced myocarditis in the A/J mouse if treatment is started early. WIN 54954 effectively reduces virus replication and islet histologic changes acutely and decreases, at 7 weeks, both the metabolic alteration associated with diabetes mellitus and the incidence of detectable viral RNA in the pancreas.|Product information|CAS Number: 107355-45-3|Molecular Weight: 383.27|Formula: C18H20Cl2N2O3|Chemical Name: Isoxazole, 5-(5-(2, 6-dichloro-4-(4, 5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methyl-|Smiles: CC1C=C(CCCCCOC2C(Cl)=CC(=CC=2Cl)C2=NCCO2)ON=1|InChiKey: JJDHAOLOHQTGMG-UHFFFAOYSA-N|InChi: InChI=1S/C18H20Cl2N2O3/c1-12-9-14(25-22-12)5-3-2-4-7-23-17-15(19)10-13(11-16(17)20)18-21-6-8-24-18/h9-11H,2-8H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|See DM, Tilles JG. WIN 54954 treatment of mice infected with a diabetogenic strain of group B coxsackievirus. Antimicrob Agents Chemother. 1993 Aug;37(8):1593-8. doi: 10.1128/AAC.37.8.1593. PMID: 8215268; PMCID: PMC188025.Heim A, Pfetzing U, Müller G, Grumbach IM. Antiviral activity of WIN 54954 in coxsackievirus B2 carrier state infected human myocardial fibroblasts.{{Hydrocortisone} web|{Hydrocortisone} Metabolic Enzyme/Protease|{Hydrocortisone} Biological Activity|{Hydrocortisone} In stock|{Hydrocortisone} custom synthesis|{Hydrocortisone} Cancer} Antiviral Res.{{FGF-8b Protein, Human/Mouse} medchemexpress|{FGF-8b Protein, Human/Mouse} Purity & Documentation|{FGF-8b Protein, Human/Mouse} Purity|{FGF-8b Protein, Human/Mouse} supplier|{FGF-8b Protein, Human/Mouse} Autophagy} 1998 Jan;37(1):47-56.PMID:24211511 doi: 10.1016/s0166-3542(97)00056-9. PMID: 9497072.Woods MG, Diana GD, Rogge MC, Otto MJ, Dutko FJ, McKinlay MA. In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother. 1989 Dec;33(12):2069-74. doi: 10.1128/AAC.33.12.2069. PMID: 2559655; PMCID: PMC172823.Ilbäck NG, Wesslén L, Pauksen K, Stålhandske T, Friman G, Fohlman J. Effects of the antiviral WIN 54954 and the immune modulator LS 2616 on cachectin/TNF and gamma-interferon responses during viral heart disease. Scand J Infect Dis Suppl. 1993;88:117-23. PMID: 8390714.Pauksen K, Ilbäck NG, Friman G, Fohlman J. Therapy of coxsackie virus B3-induced myocarditis with WIN 54954 in different formulations. Scand J Infect Dis Suppl. 1993;88:125-30. PMID: 8390715.Products are for research use only. Not for human use.|