Product Name :
SR-31747
Description:
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase.
CAS:
132173-07-0
Molecular Weight:
396.44
Formula:
C23H35Cl2N
Chemical Name:
N-[(2Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-en-1-yl]-N-ethylcyclohexanamine hydrochloride
Smiles :
Cl.CCN(C/C=C\C1=CC(Cl)=C(C=C1)C1CCCCC1)C1CCCCC1
InChiKey:
HKHPCMBPASXYGP-KVVVOXFISA-N
InChi :
InChI=1S/C23H34ClN.ClH/c1-2-25(21-13-7-4-8-14-21)17-9-10-19-15-16-22(23(24)18-19)20-11-5-3-6-12-20;/h9-10,15-16,18,20-21H,2-8,11-14,17H2,1H3;1H/b10-9-;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Rosiglitazone} medchemexpress|{Rosiglitazone} Vitamin D Related/Nuclear Receptor|{Rosiglitazone} Purity & Documentation|{Rosiglitazone} In Vitro|{Rosiglitazone} supplier|{Rosiglitazone} Cancer}
Additional information:
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties.{{Olsalazine} site|{Olsalazine} Antibiotic|{Olsalazine} Protocol|{Olsalazine} In Vitro|{Olsalazine} manufacturer|{Olsalazine} Epigenetic Reader Domain} SR-31747 blocks cell proliferation by inhibiting sterol isomerase.|Product information|CAS Number: 132173-07-0|Molecular Weight: 396.44|Formula: C23H35Cl2N|Chemical Name: N-[(2Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-en-1-yl]-N-ethylcyclohexanamine hydrochloride|Smiles: Cl.CCN(C/C=C\C1=CC(Cl)=C(C=C1)C1CCCCC1)C1CCCCC1|InChiKey: HKHPCMBPASXYGP-KVVVOXFISA-N|InChi: InChI=1S/C23H34ClN.ClH/c1-2-25(21-13-7-4-8-14-21)17-9-10-19-15-16-22(23(24)18-19)20-11-5-3-6-12-20;/h9-10,15-16,18,20-21H,2-8,11-14,17H2,1H3;1H/b10-9-;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 15.PMID:23398362 62 mg/mL (39.40 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner.|In Vivo:|In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition.|Products are for research use only. Not for human use.|