Tients with schizophrenia or schizoaffective disorder who received at the very least one dose of study medication. Table 1 presents the baseline clinical characteristics for the total study population. In the 240 sufferers switched to lurasidone from other antipsychotics, 235 individuals with offered information around the PETiT scale and SF-12 assessment comprised the ITTAwad et al. BMC Psychiatry 2014, 14:53 http://www.biomedcentral/1471-244X/14/Page 4 ofTable 1 Patient demographics and baseline clinical characteristicsParameter N Imply age Years, SD Gender Male Female Race Asian Black or African American Native Hawaiian or other Pacific Islander White Other DSM-IV Schizophrenia subtype diagnosis 295.10 Disorganized type 295.20 Catatonic type 295.30 Paranoid variety 295.60 Residual variety 295.70 Schizoaffective disorder 295.90 Undifferentiated type Preswitch antipsychotic agent at study get started Quetiapine Risperidone Aripiprazole Ziprasidone Olanzapine Paliperidone Iloperidone Asenapine First-generation antipsychotic Remedy with concomitant lithium, valproate or lamotrigine Remedy with concomitant antidepressant Imply age (SD) at initial onset of schizophrenia or schizoaffective disorder, years Imply positive and adverse syndrome scale total score (SD) Imply clinical worldwide impression severity score (SD)*or as indicated.83 of 235 (35 ) had been treated using a preswitch sedating medication (olanzapine or quetiapine).PETiT assessmentNo. of subjects ( )*43.9 (10.9)156 (65.0 ) 84 (35.0 )1 (0.4 ) 151 (62.9 ) 1 (0.four ) 80 (33.3 ) 7 (2.9 )The imply (normal deviation [SD]) PETiT total score for all lurasidone sufferers improved from 35.0 (8.8) at baseline to 38.5 (9.two) at LOCF endpoint, representing a imply improvement of three.two (eight.five) or 9.1 (p 0.001). Improvements from baseline to LOCF endpoint within the total score, at the same time as inside the domains of adherence-related attitude (0.Ivermectin 7 [2.Saxagliptin hydrochloride 6]) and psychosocial functioning (two.PMID:23695992 five [6.9]), had been statistically important (p 0.002) for all sufferers who were switched to lurasidone (Table two). All elements on the psychosocial functioning domain (activity, cognitive, and dysphoria) showed considerable improvement (p 0.002) together with the exception of social functioning, where a non-significant improvement was demonstrated.PETiT scores by preswitch antipsychotic medication4 (1.7 ) 0 125 (52.1 ) 2 (0.8 ) 89 (37.1 ) 21 (eight.eight )62 (25.eight ) 51 (21.three ) 44 (18.3 ) 27 (11.3 ) 24 (10.0 ) 9 (3.8 ) 4 (1.7 ) two (0.8 ) 17 (7.1 ) 34 (16.two ) 104 (43.three ) 25.1 (9.three) 68.9 (13.8) 3.7 (0.five)The variations in patients’ PETiT scores had been also stratified depending on the antipsychotic medication utilized before switching to lurasidone. To make sure a affordable sample size for this analysis, preswitch antipsychotic medicines received by 10 of patients inside the study were integrated for stratification. The medicines integrated quetiapine (n = 62), risperidone (n = 51), aripiprazole (n = 44), ziprasidone (n = 27), and olanzapine (n = 24). Individuals on all of those preswitch drugs except olanzapine showed statistically significant improvements in total PETiT scores, as determined by imply adjustments from baseline to LOCF ( D): quetiapine four.two (7.7), p = 0.011; risperidone 3.6 (7.9), p = 0.029; aripiprazole three.4 (8.0), p = 0.010; ziprasidone 5.four (7.9), p = 0.009 (Table 3). Sufferers on these four agents also showed considerable improvements on the psychosocial functioning component (all p 0.05) (Table three). For individuals switched from olanzapine, a numerical reduce within the total PETiT score and it.
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