Evaluated the prognostic value of preoperative levels of circulating angiogenic factors. A study on esophageal PI3Kβ Biological Activity carcinoma located that serum PD-ECGF level correlated considerably with tumor expression of PD-ECGF, and that serum PD-ECGF level was predictive of substantial tumor size, deep tumor invasion, and worse survival.172 The clinical significance of other circulating angiogenic variables in esophageal carcinoma is unknown. Yoshikawa et al.173 showed that plasma level of VEGF, but not bFGF, was an independent prognostic issue in sufferers with gastric carcinoma. Saito et al.174 discovered that higher serum TGF- 1 was associated with lymph node metastasis and poor prognosis in patients with gastric cancer. Nevertheless, serum TGF- 1 level was not a important prognostic factor inside a multivariate evaluation. A study involving 614 patients with colorectal cancer discovered greater levels of serum VEGF with advanced Dukes’ staging.175 The study discovered significantly decreased survival in sufferers with high serum VEGF levels. In a further report, the same group showed that serum VEGF, but not plasma VEGF, was an independent prognostic issue in individuals with colorectal cancer.177 Broll et al.176 also demonstrated that high serum VEGF levels had been associated with poor prognosis in individuals with colorectal cancer. Numerous other reports, even though not straight testing the prognostic worth of serum VEGF on survival, revealed that high serum VEGF levels had been predictive of lymph node metastasis and advanced tumor stage.180-183 Dirix et al.180 identified that both a higher serum VEGF level plus a higher serum bFGF level were related with fast tumor development when it comes to tumor volume TRPML manufacturer doubling times. Another study showed that serum VEGF levels, but not serum bFGF levels, were related to vascularity and volume of liver metastasis from colorectal cancer.184 Tsushima et al.178 showed that postoperative plasma TGF- 1 level measured at 2 weeks just after resection of colorectal cancer was predictive of the development of liver metastasis. One more study found that preoperative serum TGF- 1 levels were considerably correlated with the depth of tumor invasion, lymph node and distant metastases.185 No data exist on the prognostic significance of circulating VEGF, bFGF, PD-ECGF, or TGF- 1 in individuals with pancreatic cancer. However, a single study reported that individuals with an elevated serum angiogenin level were related with poor survival.159 Similarly, data on the prognostic significance of circulating angiogenic elements in individuals with hepatocellular car2003 Lippincott Williams WilkinsAnnals of Surgery Volume 238, Number 1, JulyAngiogenesis in Gastrointestinal CancersTABLE 5. Research around the Prognostic Significance of Circulating Angiogenic Aspects in Individuals with Gastrointestinal Cancers Treated by Resection Prognostic Significance Study Esophageal carcinoma Shimada et al.,172 2002 Gastric carcinoma Yoshikawa et al.,173 2000 Saito et al.,174 2000 Colorectal carcinoma Werther et al.,175 2000 Broll et al.,176 2001 Werther et al.,177 2002 Tsushima et al.,178 2001 Pancreatic carcinoma Shimoyama et al.,159 1996 Hepatocellular carcinoma Poon et al.,179 2001 Circulating Angiogenic Issue No. of Individuals Univariate Evaluation Multivariate AnalysisSerum PD-ECGF Plasma VEGF Plasma bFGF Serum TGF- 1 Serum VEGF Serum VEGF Serum VEGF Plasma VEGF Plasma TGF- 1 Serum angiogenin Serum bFGF80 54 54 111 614 122 524 524 117 47Yes Yes No Yes Yes Yes Yes Yes Yes Yes YesNo Yes No No Yes No Yes No Yes NA YesP 0.05. Two-wee.
Posted inUncategorized