Ors had a higher percentage of DDR mutations than type I tumors (70.59 vs. 28.85 , p 0.001, chi-squared test). The advancedBiomedicines 2021, 9,9 ofstage individuals had higher percentage of DDR mutations than the early-stage individuals (57.28 vs. 27.54 , p 0.001, chi-squared test). Recurring individuals had a higher percentage of DDR mutations than those without having recurrence (53.92 vs. 32.86 , p = 0.006, chi-squared test). Patients who died of EOC had a higher percentage of DDR mutations than living individuals (59.21 vs. 34.38 , p = 0.001, chi-squared test). EOC individuals with out DDR gene mutation had longer progression-free survival (PFS) (p = 0.0072, log-rank test, Figure 2A) and overall survival (OS) (p = 0.022, log-rank test, Figure 2B) than these with 1 DDR or two DDR mutations. In serous carcinoma, patients with or with no DDR mutations had related PFS (p = 0.56, log-rank test, Figure 2C). Patients with two DDR mutations had a trend of better OS than these with 1 mutation or none, nevertheless it was not statistically substantial (p = 0.47, log-rank test, Figure 2D). In endometrioid carcinoma, patients with 2 DDR gene mutations had shorter PFS (p = 0.0035, log-rank test, Figure 2E) and OS (p = 0.015, log-rank test, Figure 2F) than those with 1 mutation or none. In clear cell carcinoma, individuals with 2 DDR gene mutations had drastically shorter PFS (p = 0.0056, log-rank test, Figure 2G) and OS (p = 0.0046, log-rank test, Figure 2H) than those with 1 DDR mutation or none. Tumor recurrence with CCR gene mutation (HR: 1.68 (1.12.50), p = 0.011), 1 DDR gene mutation (HR: 1.71 (1.12.60), p = 0.013), endometrioid carcinoma (HR: 0.17 (0.08.37), p 0.001), NCGC00029283 References variety II tumor (HR: two.69 (1.81.00), p 0.001), advanced-stage carcinoma (HR: five.29 (three.16.85), p 0.001), high-grade tumor (HR: five.57 (2.263.70), p 0.001) and Pirimicarb manufacturer optimal debulking surgery (HR: 0.28 (0.18.41), p 0.001) have been considerable inside the univariate Cox regression model (Table 5). Advanced-stage carcinoma (HR: three.08 (1.63.80), p = 0.001) and optimal debulking surgery (HR: 0.51 (0.32.80), p = 0.004) had been vital prognostic elements within the multivariate evaluation. Cancer-related death with TLS gene mutation (HR: 33.76 (three.9589.00), p = 0.001), 1 DDR gene mutation (HR: 1.96 (1.20.20), p = 0.007), endometrioid carcinoma (HR: 0.12 (0.04.38), p 0.001), variety II tumor (HR: 1.88 (1.19.96), p = 0.007), advanced-stage carcinoma (HR: 6.84 (3.284.25), p 0.001), high-grade tumor (HR: 17.97 (2.5029.29), p = 0.004) and optimal debulking surgery (HR: 0.26 (0.16.41), p 0.001) had been considerable in the univariate Cox regression model. Type II tumor (HR: 0.35 (0.20.60), p 0.001), TLS gene mutation (HR: 9.57 (1.084.83), p = 0.042), advanced-stage carcinoma (HR: 4.82 (two.091.09), p 0.001) and optimal debulking surgery (HR: 0.38 (0.22.64), p 0.001) were important prognostic aspects within the multivariate analysis.Biomedicines 2021, 9,10 ofTable four. The correlation of DDR gene mutations with clinical parameters in the epithelial ovarian cancer sufferers. Genes OSA Total HR Wild variety Mutation p value NHEJ Wild kind Mutation p worth MMR Wild kind Mutation p value BER Wild variety Mutation p worth 160 93.02 12 6.98 65 94.20 four 5.80 37 94.87 2 five.13 58 90.63 six 9.38 0.631 96 92.31 eight 7.69 64 94.12 4 5.88 0.649 65 94.20 4 5.80 95 92.23 8 7.77 0.619 27 93.ten 2 6.90 133 93.01 10 six.99 0.985 66 94.29 four 5.71 94 92.16 eight 7.84 0.59 91 94.79 five five.21 69 90.79 7 9.21 0.306 161 93.60 11 six.40 67 97.ten 2 two.90 33 84.62 6 15.38 61.
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