Of mortality in the critically ill surgical patient.P50 C-reactive protein predicts mortality on admission to

Of mortality in the critically ill surgical patient.P50 C-reactive protein predicts mortality on admission to a surgical high-dependency unitF Leitch1, E Dickson1, A McBain1, S Robertson2, D O’Reilly1, C Imrie1 1Glasgow Royal Infirmary, Glasgow, UK; 2Johannesburg Hospital, Johannesburg, South Africa Critical Care 2007, 11(Suppl 2):P50 (doi: 10.1186/cc5210) Introduction C-reactive protein (CRP) is a non-specific marker that may be used to assess the magnitude of the inflammatory response in critically ill surgical patients. Our aim was to determine the temporal relationship between CRP measurement and mortality. Methods In a prospective study conducted in a surgical highdependency unit (HDU), 132 consecutive patients were evaluated. Regional Ethics Committee approval was obtained. Serum CRPSCritical CareMarch 2007 Vol 11 Suppl27th RG7800 manufacturer International Symposium on Intensive Care and Emergency Medicinewas measured on admission, day 1 and day 2 and was evaluated with respect to inhospital mortality. Results CRP on admission to HDU discriminated survivors from nonsurvivors (P < 0.0001, analysis of variance). A CRP greater than 100 mg/l correlated very strongly with mortality. The PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20799915 mortality in patients with a CRP less than 100 mg/l (n = 93) was 2.2 . The mortality in patients with a CRP greater than 100 mg/l (n = 39) was 25.6 (P < 0.0001, chi-square test), (Table 1). However, there were no significant differences in CRP with respect to mortality on day 1 or day 2 (P = 0.136 and 0.236, respectively).Table 1 (abstract P50) CRP <100 mg/l CRP >100 mg/l Inhospital mortality 2.2 (n = 93) 25.6 (n = 39) P value <0.0001 (chi-square)Conclusion The BPW has no utility in the ED to predict the development of sepsis in at-risk patients. The development of a BPW at any time during the hospital stay correlates with an increased risk of sepsis and mortality. Baseline statin therapy may reduce the chance of developing a BPW.P52 Functional protein C levels in septic patientsE Lafuente, I Pratima, M Fernandes, J Gomes da Silva, F Moura, F Santos, I Guimaraes, R Lopes, P Santos Padre Americo, Penafiel, Portugal Critical Care 2007, 11(Suppl 2):P52 (doi: 10.1186/cc5212) Objective To know whether functional protein C (FPC) levels in critical septic patients could be intended as an evolution marker correlated with prognosis and mortality. Materials and methods A prospective study with determination of FPC levels in all septic patients admitted to the ICU. We used the IL testTM PC kit (Instrumentation Laboratory; synthetic chromogenic substrate). We considered an abnormal low FPC when levels were below 40 , normal FPC when levels were above 80 and low FPC when levels where between 40 and 80 . Data included patient age, diagnosis, SAPS II, SOFA score, OSF and mortality. The analytical data included serum lactate and FPC. Patients were divided into three groups: group I (FPC below 40 ), group II (FPC 40?0 ) and group III (FPC above 80 ). The statistical study was performed with the Analyse-it?program. The severity was defined by the usual criteria of SAPS II score and lactate levels and then compared with the different FPC groups. Mortality was considered. Results We included 65 patients. The total mortality rate was 16.9 (11 patients).Table 1 (abstract P52) n = 65 Group I Group II Group III FPC 30.9 ?9 58.1 ?13 100.8 ?12.8 Lactate 15.7 ?5.8 1.8 ?0.35 1.3 ?0.9 <0.05 P <0.05 Mortality ( ) 78 22Conclusion CRP on admission to the surgical HDU is a powerful predictor of mo.