Eral vein had been randomised to get a 20 alanyl-glutamine (Dipeptiven, Fresenius-Kabi) infusion of

Eral vein had been randomised to get a 20 alanyl-glutamine (Dipeptiven, Fresenius-Kabi) infusion of 0.5 g/kg or precisely the same volume of saline throughout four h in a peripheral vein on three consecutive days. The venous lines (BD Venflon?i.v.; 1.0 mm diameter) were inserted particularly for this purpose, and removed soon after each infusion. Diverse veins in the identical arm had been utilised. Regional tolerance was evaluated clinically by Maddox score, and ultrasonically (AspenTM Ultrasound System equipped with L10 transducer with frequency 11? MHz) prior to the infusion and on days 1, four and eight immediately after the infusion. Results: In the study 56 out of 60 (93 ) planned infusions have been administered and 157 out of 168 (93 ) clinical evaluations have been successfully performed. The ultrasonic evaluation revealed that the utilized veins had a diameter of 2.15 ?0.eight mm (imply ?SD; variety 1.0?.4 mm; n = 56) 3 cm proximal from the insertion website. Making use of the protocol described above, there were no signs of thrombophlebitis in any single individuals by either Maddox score or ultrasound. Conclusion: Administration of glutamine-containing dipeptide concentrate (20 ) by peripheral veins is protected in terms of local tolerance, if a strict protocol is adapted for this objective involving a separate line for the infusion removed instantly afterwards.P125 Serum amylin correlates with delayed gastric emptying in critically ill childrenA Mayer, S Skellett, A Durward, SM Tibby, C Turner, N Dalton, IA Murdoch Department Paediatric Intensive Care, Guy’s Hospital, London SE1 9RT, UK Introduction: Delayed gastric emptying is typical in critically ill individuals. Amylin is really a novel 37 amino acid polypeptide, which can be co-localised and cosecreted with insulin by pancreatic beta cells [1]. In conjunction with its part in glucose homeostasis it really is a potent inhibitor of gastric motility [2]. Thus we hypothesised that higher circulating levels of amylin could be associated with delayed gastric emptying PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20718733 in critically ill youngsters.SCritical CareVol five Suppl21st International Symposium on Intensive Care and Emergency MedicineMethod: Nineteen kids had been enrolled within 48 hours of ICU admission. Exclusion criteria included: liver illness, gastrointestinal abnormalities and use of prokinetic agents. All sufferers were N.P.O., and maintained on a ivi glucose (five? mg/kg/min). Gastric emptying (GE) was assessed clinically by feed intolerance and applying a paracetamol absorption approach (PTA). Feed intolerance was defined as a residual gastric volume > 0.25 ml/kg after 4 hours of a bolus two ml/kg test milk feed. At this point (T0), a single 15 mg/kg dose of paracetamol was administered nasogastrically, and serial blood samples taken for paracetamol assay at 0, 15, 30, 60, 120, 240 and 360 min. GE was calculated making use of the gastric emptying ratio (GER) that is the time to attain peak paracetamol level divided by its peak CFI-402257 biological activity concentration, with higher values reflecting delayed gastric emptying [3]. Blood amylin and insulin sample have been taken at T0 and T360 with all the imply of those two values made use of to reflect the average level over the study period. Amylin was measured by radioimmunoassay. Data have been assumed non-parametric, as a result Spearman’s correlation coefficient and Mann hitney tests were utilised. Data are shown as median (interquartile variety).Results: Nineteen individuals have been enrolled with a median age 6 years (1.7?.5), and weight 20 kg (11.five?1.five). Diagnoses integrated sepsis (n = eight), respiratory (n = five), head injury (n = 2), neurology (n = 2) as well as other (n = two).