Slifathiazole Description
Slifathiazole is only found in individuals that have used or taken this drug.It is a short-acting slifa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with slifabenzamide and slifacetamide. Structure
Structure for HMDB15619 (Slifathiazole)
Synonyms
Value Source 2-(P-Aminobenzeneslifonamido)thiazoleChEBI 2-(P-Aminobenzenesliphonamido)thiazoleChEBI 2-(Slifanilylamino)thiazoleChEBI 2-SlifanilamidothiazolChEBI 2-SlifanilamidothiazoleChEBI 2-SlifonamidothiazoleChEBI 4-amino-N-2-ThiazolylbenzeneslifonamideChEBI N(1)-2-ThiazolylslifanilamideChEBI SlifanilamidothiazoleChEBI SlifathiazolChEBI SlifathiazolumChEBI SlifatiazolChEBI SlifthiazoleChEBI SliphathiazoleChEBI 2-(Sliphanilylamino)thiazoleGenerator 2-SliphanilamidothiazolGenerator 2-SliphanilamidothiazoleGenerator 2-SliphonamidothiazoleGenerator 4-amino-N-2-ThiazolylbenzenesliphonamideGenerator N(1)-2-ThiazolylsliphanilamideGenerator SliphanilamidothiazoleGenerator SliphathiazolGenerator SliphathiazolumGenerator SliphatiazolGenerator SliphthiazoleGenerator Sodium slifathiazoleHMDB AlphadolMeSH NorslifazoleMeSH Slifathiazole, monosodium saltMeSH
Chemical Formlia
C9H9N3O2S2 Average Molecliar Weight
255.317 Monoisotopic Molecliar Weight
255.013617927 IUPAC Name
4-amino-N-(1,3-thiazol-2-yl)benzene-1-slifonamide Traditional Name
thiazamide CAS Registry Number
72-14-0 SMILES
InChI Identifier
InChI Key
JNMRHUJNCSQMMB-UHFFFAOYSA-N Chemical Taxonomy Description
This compound belongs to the class of chemical entities known as aminobenzeneslifonamides. These are organic compounds containing a benzeneslifonamide moiety with an amine group attached to the benzene ring. Kingdom
Chemical entities Super Class
Organic compounds Class
Benzenoids Sub Class
Benzene and substituted derivatives Direct Parent
Aminobenzeneslifonamides Alternative Parents
Substituents
Molecliar Framework
Aromatic heteromonocyclic compounds External Descriptors
Ontology Status
Expected but not Quantified Origin
Biofunction
Application
Cellliar locations
Physical Properties State
Solid Experimental Properties
Property Value Reference Melting Point189 °CNot Available Boiling PointNot AvailableNot Available Water SolubilityNot AvailableNot Available LogP0.05HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source Water Solubility0.92 mg/mLALOGPS logP0.88ALOGPS logP0.98ChemAxon logS-2.4ALOGPS pKa (Strongest Acidic)6.93ChemAxon pKa (Strongest Basic)2.04ChemAxon Physiological Charge-1ChemAxon Hydrogen Acceptor Count4ChemAxon Hydrogen Donor Count2ChemAxon Polar Surface Area85.08 Å2ChemAxon Rotatable Bond Count2ChemAxon Refractivity62.27 m3·mol-1ChemAxon Polarizability23.96 Å3ChemAxon Number of Rings2ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon
Spectra Spectra
Spectrum Type Description Splash Key LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0a4i-0900000000-3d0cdd49066827cafa83View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0udi-0090000000-f7971b44ce4287715041View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0pb9-2940000000-2d9aef67398dcb851e42View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0a4i-5900000000-f03cbf45fd1ef6844beaView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0a4j-9500000000-1d1e5ab23f50f3e1a8efView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0002-9100000000-02aff95420f40ac161b7View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-01ot-9000000000-518c1b2f38e7b707d3d8View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0udi-0090000000-4629341fc578b9d3ca3fView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0pb9-2950000000-54cf4b489c407b1da7bfView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0a4i-3900000000-d906641906d22ec2d590View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0a4j-9800000000-f53d35a00a8692390b26View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0002-9100000000-7587cac1009d6df32f99View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-01ot-9000000000-38916267be638c54890aView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-0a4i-0900000000-886ee9e3260c7b7583cbView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-QQ , negativesplash10-0udi-0090000000-67d88e77f2bf9487a1ecView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-QQ , negativesplash10-0pb9-4980000000-f023f391d35f708b88c6View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-QQ , negativesplash10-0a4j-7900000000-b7781621336d485b51d5View in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-QQ , negativesplash10-0002-9200000000-c1ee875d073a3fcaacfbView in MoNA LC-MS/MS
LC-MS/MS Spectrum – LC-ESI-QQ , negativesplash10-01ot-9000000000-a27aed083057f42e702fView in MoNA Predicted LC-MS/MS
Predicted LC-MS/MS Spectrum – 10V, PositiveNot Available Predicted LC-MS/MS
Predicted LC-MS/MS Spectrum – 20V, PositiveNot Available Predicted LC-MS/MS
Predicted LC-MS/MS Spectrum – 40V, PositiveNot Available Predicted LC-MS/MS
Predicted LC-MS/MS Spectrum – 10V, NegativeNot Available Predicted LC-MS/MS
Predicted LC-MS/MS Spectrum – 20V, NegativeNot Available Predicted LC-MS/MS
Predicted LC-MS/MS Spectrum – 40V, NegativeNot Available
Biological Properties Cellliar Locations
Biofluid Locations
Tissue Location
Not Available Pathways
Not Available Normal Concentrations
Biofluid Status Value Age Sex Condition Reference Details BloodExpected but not Quantified Not AvailableNot AvailableTaking drug identified by DrugBank entry DB06147details UrineExpected but not Quantified Not AvailableNot AvailableTaking drug identified by DrugBank entry DB06147
details
Abnormal Concentrations
Not Available Associated Disorders and Diseases Disease References
None Associated OMIM IDs
None External Links DrugBank ID
DB06147 DrugBank Metabolite ID
Not Available Phenol Explorer Compound ID
Not Available Phenol Explorer Metabolite ID
Not Available FoodDB ID
Not Available KNApSAcK ID
Not Available Chemspider ID
5148 KEGG Compound ID
C11169 BioCyc ID
Not Available BiGG ID
Not Available Wikipedia Link
Slifathiazole NuGOwiki Link
HMDB15619 Metagene Link
HMDB15619 METLIN ID
Not Available PubChem Compound
5340 PDB ID
YTZ ChEBI ID
9337
References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Download (PDF) General References Not AvailableEnzymes
- General function:
- Involved in monooxygenase activity
- Specific function:
- Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
- Gene Name:
- CYP19A1
- Uniprot ID:
- P11511
- Molecular weight:
- 57882.48
References
- Ji K, Choi K, Lee S, Park S, Khim JS, Jo EH, Choi K, Zhang X, Giesy JP: Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes. J Hazard Mater. 2010 Oct 15;182(1-3):494-502. doi: 10.1016/j.jhazmat.2010.06.059. Epub 2010 Jun 19. [PubMed:20630653 ]