Methsuximide
Methsuximide is only found in individuals that have used or taken this drug. It is an anticonvlisant medication. It is sold by Pfizer under the name Petinutin. [Wikipedia]Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the “low-voltage activated (LVA)” group and are strongly blocked by mibefradil. A particliarity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascliar smooth muscle. They may also be involved in the modliation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Structure for HMDB15611 (Methsuximide)
C12H13NO2
203.2371
203.094628665
1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
methsuximide
77-41-8
AJXPJJZHWIXJCJ-UHFFFAOYSA-N
This compound belongs to the class of chemical entities known as phenylpyrrolidines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrolidine ring through a CC or CN bond. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms.
Chemical entities
Organic compounds
Organoheterocyclic compounds
Pyrrolidines
Phenylpyrrolidines
Aromatic heteromonocyclic compounds
Not Available
Expected but not Quantified
Solid
LC-MS/MS Spectrum – LC-ESI-QFT , positivesplash10-0udi-0390000000-00d729cf9e85b7d75068View in MoNA
LC-MS/MS Spectrum – LC-ESI-QFT , positivesplash10-0udi-1690000000-0a263ad37a0831b81fb3View in MoNA
LC-MS/MS Spectrum – LC-ESI-QFT , positivesplash10-014i-4910000000-eb0a383017c0566e6a11View in MoNA
LC-MS/MS Spectrum – LC-ESI-QFT , positivesplash10-014l-9800000000-5df2aae06682d9488eefView in MoNA
LC-MS/MS Spectrum – LC-ESI-QFT , positivesplash10-05mo-9400000000-6de622fc3efce00a0b34View in MoNA
LC-MS/MS Spectrum – LC-ESI-QFT , positivesplash10-052f-9300000000-1e2faae8b516a3fc7ad5View in MoNA
Predicted LC-MS/MS Spectrum – 10V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 20V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 40V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 10V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 20V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 40V, NegativeNot Available
Mass Spectrum (Electron Ionization)splash10-014i-4910000000-aa3742fc04cdbcda351fView in MoNA
Not Available
Not Available
Not Available
None
None
DB05246
Not Available
Not Available
Not Available
Not Available
Not Available
6231
Not Available
Not Available
Not Available
Methsuximide
HMDB15611
HMDB15611
Not Available
6476
Not Available
131857
- Besag FM, Berry DJ, Pool F: Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction. Epilepsia. 2000 May;41(5):624-7. [PubMed:10802770 ]
- Hurst DL: Methsuximide therapy of juvenile myoclonic epilepsy. Seizure. 1996 Mar;5(1):47-50. [PubMed:8777552 ]
Enzymes
- General function:
- Involved in monooxygenase activity
- Specific function:
- Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
- Gene Name:
- CYP2C19
- Uniprot ID:
- P33261
- Molecular weight:
- 55944.565
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- General function:
- Involved in ion channel activity
- Specific function:
- Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the “low-voltage activated (LVA)” group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes
- Gene Name:
- CACNA1G
- Uniprot ID:
- O43497
- Molecular weight:
- 262468.6
References
- Gomora JC, Daud AN, Weiergraber M, Perez-Reyes E: Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol. 2001 Nov;60(5):1121-32. [PubMed:11641441 ]
- Coulter DA, Huguenard JR, Prince DA: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 1989 Jun;25(6):582-93. [PubMed:2545161 ]
- Wang G, Thompson SM: Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. J Neurosci. 2008 Nov 12;28(46):11959-69. doi: 10.1523/JNEUROSCI.3296-08.2008. [PubMed:19005061 ]
- Matthews EA, Dickenson AH: Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats. Eur J Pharmacol. 2001 Mar;415(2-3):141-9. [PubMed:11274992 ]