| Common Name |
Tyrosyl-Glutamate
| Description |
Tyrosyl-Glutamate is a dipeptide composed of tyrosine and glutamate. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDFPDBSMILESInChI
Structure for HMDB29104 (Tyrosyl-Glutamate)
| Synonyms |
| Value |
Source |
L-Tyrosyl-L-glutamateHMDB
Tyr-gluHMDB
Tyrosine glutamate dipeptideHMDB
Tyrosine-glutamate dipeptideHMDB
TyrosylglutamateHMDB
Y-e dipeptideHMDB
YE dipeptideHMDB
| Chemical Formlia |
C14H17N2O6
| Average Molecliar Weight |
309.2946
| Monoisotopic Molecliar Weight |
309.108661286
| IUPAC Name |
2-[2-amino-3-(4-hydroxyphenyl)propanamido]-4-carboxybutanoate
| Traditional Name |
2-[2-amino-3-(4-hydroxyphenyl)propanamido]-4-carboxybutanoate
| CAS Registry Number |
Not Available
| SMILES |
NC(CC1=CC=C(O)C=C1)C(=O)NC(CCC(O)=O)C([O-])=O
| InChI Identifier |
InChI=1S/C14H18N2O6/c15-10(7-8-1-3-9(17)4-2-8)13(20)16-11(14(21)22)5-6-12(18)19/h1-4,10-11,17H,5-7,15H2,(H,16,20)(H,18,19)(H,21,22)/p-1
| InChI Key |
PDSLRCZINIDLMU-UHFFFAOYSA-M
| Chemical Taxonomy |
| Classification |
Not classified
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-2.72Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility1.25 mg/mLALOGPS
logP-2.2ALOGPS
logP-2.7ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)3.21ChemAxon
pKa (Strongest Basic)8.02ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area152.78 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity86.02 m3·mol-1ChemAxon
Polarizability29.79 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB29104
| Metagene Link |
HMDB29104
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: E7820
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Magherini F, Busti S, Gamberi T, Sacco E, Raugei G, Manao G, Ramponi G, Modesti A, Vanoni M: In Saccharomyces cerevisiae an unbalanced level of tyrosine phosphorylation down-regulates the Ras/PKA pathway. Int J Biochem Cell Biol. 2006 Mar;38(3):444-60. Epub 2005 Nov 2. [PubMed:16297653 ]
- Kessler M, Baudry M, Cummins JT, Way S, Lynch G: Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs. J Neurosci. 1986 Feb;6(2):355-63. [PubMed:2869112 ]
|
PMID: 12738034
