| Common Name |
Tyrosyl-Gamma-glutamate
| Description |
Tyrosyl-Gamma-glutamate is a dipeptide composed of tyrosine and gamma-glutamate. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDFPDBSMILESInChI
Structure for HMDB29119 (Tyrosyl-Gamma-glutamate)
| Synonyms |
| Value |
Source |
L-Tyrosyl-L-gamma-glutamateHMDB
Tyr-ggluHMDB
Tyrosine gamma-glutamate dipeptideHMDB
Tyrosine-gamma-glutamate dipeptideHMDB
Tyrosylgamma-glutamateHMDB
Y-ge dipeptideHMDB
YGE dipeptideHMDB
| Chemical Formlia |
C14H19N3O5
| Average Molecliar Weight |
309.3178
| Monoisotopic Molecliar Weight |
309.132470733
| IUPAC Name |
2-amino-5-[2-amino-3-(4-hydroxyphenyl)propanamido]-5-oxopentanoic acid
| Traditional Name |
2-amino-5-[2-amino-3-(4-hydroxyphenyl)propanamido]-5-oxopentanoic acid
| CAS Registry Number |
Not Available
| SMILES |
NC(CCC(=O)NC(=O)C(N)CC1=CC=C(O)C=C1)C(O)=O
| InChI Identifier |
InChI=1S/C14H19N3O5/c15-10(14(21)22)5-6-12(19)17-13(20)11(16)7-8-1-3-9(18)4-2-8/h1-4,10-11,18H,5-7,15-16H2,(H,21,22)(H,17,19,20)
| InChI Key |
NHXCEHCKISFORA-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as tyrosine and derivatives. These are compounds containing tyrosine or a derivative thereof resliting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Tyrosine and derivatives
| Alternative Parents |
Phenylalanine and derivatives
Glutamine and derivatives
Alpha amino acid amides
Alpha amino acids
Amphetamines and derivatives
Aralkylamines
1-hydroxy-2-unsubstituted benzenoids
N-acyl amines
Dicarboximides
N-unsubstituted carboxylic acid imides
Amino acids
Monocarboxylic acids and derivatives
Carboxylic acids
Monoalkylamines
Hydrocarbon derivatives
Organic oxides
Carbonyl compounds
Organopnictogen compounds
| Substituents |
Tyrosine or derivatives
Phenylalanine or derivatives
Glutamine or derivatives
Alpha-amino acid amide
Alpha-amino acid
Amphetamine or derivatives
1-hydroxy-2-unsubstituted benzenoid
Phenol
Aralkylamine
Monocyclic benzene moiety
N-acyl-amine
Benzenoid
Carboxylic acid imide
Dicarboximide
Carboxylic acid imide, n-unsubstituted
Amino acid
Monocarboxylic acid or derivatives
Carboxylic acid
Organonitrogen compound
Amine
Primary aliphatic amine
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Organic oxide
Organopnictogen compound
Organooxygen compound
Hydrocarbon derivative
Primary amine
Aromatic homomonocyclic compound
| Molecliar Framework |
Aromatic homomonocyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.12Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility0.37 mg/mLALOGPS
logP-2.1ALOGPS
logP-3.1ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)2.02ChemAxon
pKa (Strongest Basic)9.15ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area155.74 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity77.13 m3·mol-1ChemAxon
Polarizability31.15 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB29119
| Metagene Link |
HMDB29119
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: Epiberberine (chloride)
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
Not Available |
PMID: 9144661
