Prolyl-Valine Description
Prolyl-Valine is a dipeptide composed of proline and valine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite. Structure
Structure for HMDB29030 (Prolyl-Valine)
Synonyms
Value Source L-Prolyl-L-valineHMDB P-V DipeptideHMDB pro-ValHMDB Proline valine dipeptideHMDB Proline-valine dipeptideHMDB ProlylvalineHMDB PV DipeptideHMDB
Chemical Formlia
C10H18N2O3 Average Molecliar Weight
214.2615 Monoisotopic Molecliar Weight
214.131742452 IUPAC Name
3-methyl-2-(pyrrolidin-2-ylformamido)butanoic acid Traditional Name
3-methyl-2-(pyrrolidin-2-ylformamido)butanoic acid CAS Registry Number
Not Available SMILES
InChI Identifier
InChI Key
AWJGUZSYVIVZGP-UHFFFAOYSA-N Chemical Taxonomy Description
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Kingdom
Chemical entities Super Class
Organic compounds Class
Organic acids and derivatives Sub Class
Carboxylic acids and derivatives Direct Parent
Dipeptides Alternative Parents
Substituents
Molecliar Framework
Aliphatic heteromonocyclic compounds External Descriptors
Not Available Ontology Status
Expected but not Quantified Origin
Biofunction
Not Available Application
Not Available Cellliar locations
Not Available Physical Properties State
Solid Experimental Properties
Property Value Reference Melting PointNot AvailableNot Available Boiling PointNot AvailableNot Available Water SolubilityNot AvailableNot Available LogP-2.22Extrapolated
Predicted Properties
Property Value Source Water Solubility16.9 mg/mLALOGPS logP-2ALOGPS logP-2.2ChemAxon logS-1.1ALOGPS pKa (Strongest Acidic)3.85ChemAxon pKa (Strongest Basic)9.81ChemAxon Physiological Charge0ChemAxon Hydrogen Acceptor Count4ChemAxon Hydrogen Donor Count3ChemAxon Polar Surface Area78.43 Å2ChemAxon Rotatable Bond Count4ChemAxon Refractivity54.36 m3·mol-1ChemAxon Polarizability22.49 Å3ChemAxon Number of Rings1ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon
Spectra Spectra
Not Available Biological Properties Cellliar Locations
Not Available Biofluid Locations
Not Available Tissue Location
Not Available Pathways
Not Available Normal Concentrations Not Available Abnormal Concentrations
Not Available Associated Disorders and Diseases Disease References
None Associated OMIM IDs
None External Links DrugBank ID
Not Available DrugBank Metabolite ID
Not Available Phenol Explorer Compound ID
Not Available Phenol Explorer Metabolite ID
Not Available FoodDB ID
Not Available KNApSAcK ID
Not Available Chemspider ID
Not Available KEGG Compound ID
Not Available BioCyc ID
Not Available BiGG ID
Not Available Wikipedia Link
Not Available NuGOwiki Link
HMDB29030 Metagene Link
HMDB29030 METLIN ID
Not Available PubChem Compound
Not Available PDB ID
Not Available ChEBI ID
Not Available
References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Not Available General References- Hara Y, Kanagawa M, Kunz S, Yoshida-Moriguchi T, Satz JS, Kobayashi YM, Zhu Z, Burden SJ, Oldstone MB, Campbell KP: Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17426-31. doi: 10.1073/pnas.1114836108. Epub 2011 Oct 10. [PubMed:21987822 ]
- Berglund A, Head RD, Welsh EA, Marshall GR: ProVal: a protein-scoring function for the selection of native and near-native folds. Proteins. 2004 Feb 1;54(2):289-302. [PubMed:14696191 ]
- Myara I, Marcon P, Lemonnier A, Chatelier B, Mangeot M: Determination of prolinase activity in plasma. Application to liver disease and its relation with prolidase activity. Clin Biochem. 1985 Aug;18(4):220-3. [PubMed:4042319 ]
- Dupuis B, Garcia N, Boels G: Efficacy of potato seeds disinfection products to control Erwinia spp. Commun Agric Appl Biol Sci. 2008;73(2):343-8. [PubMed:19226773 ]