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Methionyl-Methionine

July 21, 2017
Common Name

Methionyl-Methionine Description

Methionyl-Methionine is a dipeptied compoosed of two methionine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite. Structure

MOLSDF3D-SDFPDBSMILESInChI View 3D Structure

Structure for HMDB28979 (Methionyl-Methionine)

Synonyms

Value Source L-Methionyl-L-methionineHMDB m-m DipeptideHMDB Met-metHMDB Methionine methionine dipeptideHMDB Methionine-methionine dipeptideHMDB MethionylmethionineHMDB MM DipeptideHMDB Methionylmethionine, (L-met-L-met)-isomerMeSH DL-MethionylmethionineMeSH

Chemical Formlia

C10H20N2O3S2 Average Molecliar Weight

280.407 Monoisotopic Molecliar Weight

280.091533896 IUPAC Name

2-[2-amino-4-(methylslifanyl)butanamido]-4-(methylslifanyl)butanoic acid Traditional Name

2-[2-amino-4-(methylslifanyl)butanamido]-4-(methylslifanyl)butanoic acid CAS Registry Number

Not Available SMILES

CSCCC(N)C(=O)NC(CCSC)C(O)=O

InChI Identifier

InChI=1S/C10H20N2O3S2/c1-16-5-3-7(11)9(13)12-8(10(14)15)4-6-17-2/h7-8H,3-6,11H2,1-2H3,(H,12,13)(H,14,15)

InChI Key

ZYTPOUNUXRBYGW-UHFFFAOYSA-N Chemical Taxonomy Description

This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Kingdom

Chemical entities Super Class

Organic compounds Class

Organic acids and derivatives Sub Class

Carboxylic acids and derivatives Direct Parent

Dipeptides Alternative Parents

  • Methionine and derivatives
  • N-acyl-alpha amino acids
  • Alpha amino acid amides
  • Thia fatty acids
  • N-acyl amines
  • Secondary carboxylic acid amides
  • Amino acids
  • Slifenyl compounds
  • Carboxylic acids
  • Dialkylthioethers
  • Monocarboxylic acids and derivatives
  • Carbonyl compounds
  • Hydrocarbon derivatives
  • Organic oxides
  • Monoalkylamines
  • Organopnictogen compounds

    • Substituents

  • Alpha-dipeptide
  • Methionine or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • Alpha-amino acid or derivatives
  • Thia fatty acid
  • Fatty amide
  • N-acyl-amine
  • Fatty acid
  • Fatty acyl
  • Amino acid
  • Secondary carboxylic acid amide
  • Amino acid or derivatives
  • Carboxamide group
  • Slifenyl compound
  • Thioether
  • Dialkylthioether
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Organic nitrogen compound
  • Organic oxide
  • Primary aliphatic amine
  • Organonitrogen compound
  • Organooxygen compound
  • Carbonyl group
  • Organoslifur compound
  • Primary amine
  • Organic oxygen compound
  • Amine
  • Aliphatic acyclic compound

    • Molecliar Framework

    Aliphatic acyclic compounds External Descriptors

    Not Available Ontology Status

    Expected but not Quantified Origin

  • Endogenous

    • Biofunction

    Not Available Application

    Not Available Cellliar locations

    Not Available Physical Properties State

    Solid Experimental Properties

    Property Value Reference Melting PointNot AvailableNot Available Boiling PointNot AvailableNot Available Water SolubilityNot AvailableNot Available LogP-2.08Extrapolated

    Predicted Properties

    Property Value Source Water Solubility3.03 mg/mLALOGPS logP-0.42ALOGPS logP-2.1ChemAxon logS-2ALOGPS pKa (Strongest Acidic)3.86ChemAxon pKa (Strongest Basic)8.42ChemAxon Physiological Charge0ChemAxon Hydrogen Acceptor Count4ChemAxon Hydrogen Donor Count3ChemAxon Polar Surface Area92.42 Å2ChemAxon Rotatable Bond Count9ChemAxon Refractivity71.97 m3·mol-1ChemAxon Polarizability29.94 Å3ChemAxon Number of Rings0ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon

    Spectra Spectra

    Not Available Biological Properties Cellliar Locations

    Not Available Biofluid Locations

    Not Available Tissue Location

    Not Available Pathways

    Not Available Normal Concentrations Not Available Abnormal Concentrations

    Not Available Associated Disorders and Diseases Disease References

    None Associated OMIM IDs

    None External Links DrugBank ID

    Not Available DrugBank Metabolite ID

    Not Available Phenol Explorer Compound ID

    Not Available Phenol Explorer Metabolite ID

    Not Available FoodDB ID

    Not Available KNApSAcK ID

    Not Available Chemspider ID

    Not Available KEGG Compound ID

    Not Available BioCyc ID

    Not Available BiGG ID

    Not Available Wikipedia Link

    Not Available NuGOwiki Link

    HMDB28979 Metagene Link

    HMDB28979 METLIN ID

    Not Available PubChem Compound

    Not Available PDB ID

    Not Available ChEBI ID

    Not Available

    Product: Imipramine (hydrochloride)

    References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Not Available General References
    1. Alfimova MV, Korovaitseva GI, Lezheiko TV, Golimbet VE: Effect of BDNF Val66Met polymorphism on normal variability of executive functions. Bull Exp Biol Med. 2012 Mar;152(5):606-9. [PubMed:22803145 ]
    2. Hug GL, Bobrowski K, Kozubek H, Marciniak B: Photo-oxidation of methionine-containing peptides by the 4-carboxybenzophenone triplet state in aqueous solution. Competition between intramolecular two-centered three-electron bonded (S…S)+ and (S…N)+ formation. Photochem Photobiol. 2000 Jul;72(1):1-9. [PubMed:10911722 ]
    3. Baker DH, Bafundo KW, Boebel KP, Czarnecki GL, Halpin KM: Methionine peptides as potential food supplements: efficacy and susceptibility to Maillard browning. J Nutr. 1984 Feb;114(2):292-7. [PubMed:6693991 ]
    4. Marco-Pallares J, Nager W, Kramer UM, Cunillera T, Camara E, Cucurell D, Schule R, Schols L, Rodriguez-Fornells A, Munte TF: Neurophysiological markers of novelty processing are modulated by COMT and DRD4 genotypes. Neuroimage. 2010 Nov 15;53(3):962-9. doi: 10.1016/j.neuroimage.2010.02.012. Epub 2010 Feb 12. [PubMed:20156565 ]
    5. Friedman M, Gumbmann MR: Nutritional value and safety of methionine derivatives, isomeric dipeptides and hydroxy analogs in mice. J Nutr. 1988 Mar;118(3):388-97. [PubMed:3351635 ]
    6. Boebel KP, Baker DH: Efficacy of methionine peptides as determined by chick bioassay. J Nutr. 1982 Jun;112(6):1130-2. [PubMed:7086542 ]

    PMID: 7851485

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