Lysyl-Lysine Description
Lysyl-Lysine is a dipeptied compoosed of two lysine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite. Structure
Structure for HMDB28956 (Lysyl-Lysine)
Synonyms
Value Source K-K DipeptideHMDB KK DipeptideHMDB L-Lysyl-L-lysineHMDB Lys-lysHMDB Lysine lysine dipeptideHMDB Lysine-lysine dipeptideHMDB LysyllysineHMDB Lysyllysine dihydrochlorideMeSH Lysyllysine hydrochlorideMeSH Lysyllysine mono-trifluoroacetateMeSH L-Lys-L-lysMeSH
Chemical Formlia
C12H26N4O3 Average Molecliar Weight
274.3598 Monoisotopic Molecliar Weight
274.200490718 IUPAC Name
6-amino-2-(2,6-diaminohexanamido)hexanoic acid Traditional Name
6-amino-2-(2,6-diaminohexanamido)hexanoic acid CAS Registry Number
Not Available SMILES
InChI Identifier
InChI Key
NVGBPTNZLWRQSY-UHFFFAOYSA-N Chemical Taxonomy Description
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Kingdom
Chemical entities Super Class
Organic compounds Class
Organic acids and derivatives Sub Class
Carboxylic acids and derivatives Direct Parent
Dipeptides Alternative Parents
Substituents
Molecliar Framework
Aliphatic acyclic compounds External Descriptors
Not Available Ontology Status
Expected but not Quantified Origin
Biofunction
Not Available Application
Not Available Cellliar locations
Not Available Physical Properties State
Solid Experimental Properties
Property Value Reference Melting PointNot AvailableNot Available Boiling PointNot AvailableNot Available Water SolubilityNot AvailableNot Available LogP-3.97Extrapolated
Predicted Properties
Property Value Source Water Solubility2.38 mg/mLALOGPS logP-3.1ALOGPS logP-4ChemAxon logS-2.1ALOGPS pKa (Strongest Acidic)3.85ChemAxon pKa (Strongest Basic)10.51ChemAxon Physiological Charge2ChemAxon Hydrogen Acceptor Count6ChemAxon Hydrogen Donor Count5ChemAxon Polar Surface Area144.46 Å2ChemAxon Rotatable Bond Count11ChemAxon Refractivity72.42 m3·mol-1ChemAxon Polarizability31.07 Å3ChemAxon Number of Rings0ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon
Spectra Spectra
Not Available Biological Properties Cellliar Locations
Not Available Biofluid Locations
Not Available Tissue Location
Not Available Pathways
Not Available Normal Concentrations Not Available Abnormal Concentrations
Not Available Associated Disorders and Diseases Disease References
None Associated OMIM IDs
None External Links DrugBank ID
Not Available DrugBank Metabolite ID
Not Available Phenol Explorer Compound ID
Not Available Phenol Explorer Metabolite ID
Not Available FoodDB ID
Not Available KNApSAcK ID
Not Available Chemspider ID
Not Available KEGG Compound ID
Not Available BioCyc ID
Not Available BiGG ID
Not Available Wikipedia Link
Not Available NuGOwiki Link
HMDB28956 Metagene Link
HMDB28956 METLIN ID
Not Available PubChem Compound
Not Available PDB ID
Not Available ChEBI ID
Not Available
References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Not Available General References- Thorne BA, Viveros OH, Thomas G: Expression and processing of mouse proopiomelanocortin in bovine adrenal chromaffin cells. A model system to study tissue-specific prohormone processing. J Biol Chem. 1991 Jul 25;266(21):13607-15. [PubMed:1856197 ]
- Graf J, Hodgson R, van Daal A: Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation. Hum Mutat. 2005 Mar;25(3):278-84. [PubMed:15714523 ]
- Perron MS, Gobeil F Jr, Pelletier S, Regoli D, Sirois P: Involvement of bradykinin B1 and B2 receptors in pulmonary leukocyte accumulation induced by Sephadex beads in guinea pigs. Eur J Pharmacol. 1999 Jul 2;376(1-2):83-9. [PubMed:10440093 ]
- Jun YJ, Kim JH, Choi SJ, Lee HJ, Jun MJ, Sohn YS: A tetra(L-lysine)-grafted poly(organophosphazene) for gene delivery. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2975-8. Epub 2007 Mar 25. [PubMed:17428658 ]
- Staffilani M, Hoss E, Giesen U, Schneider E, Hartl F, Josel HP, De Cola L: Multimetallic ruthenium(II) complexes as electrochemiluminescent labels. Inorg Chem. 2003 Dec 1;42(24):7789-98. [PubMed:14632494 ]
- Dray A, Patel IA, Perkins MN, Rueff A: Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro. Br J Pharmacol. 1992 Dec;107(4):1129-34. [PubMed:1334751 ]