| Common Name |
Leucyl-Hydroxyproline
| Description |
Leucyl-Hydroxyproline is a dipeptide composed of leucine and hydroxyproline. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB28930 (Leucyl-Hydroxyproline)
| Synonyms |
| Value |
Source |
Leucine hydroxyproline dipeptideHMDB
L-HP DipeptideHMDB
L-Leucyl-L-hydroxyprolineHMDB
Leu-hproHMDB
Leucine-hydroxyproline dipeptideHMDB
LeucylhydroxyprolineHMDB
LHP DipeptideHMDB
| Chemical Formlia |
C11H20N2O4
| Average Molecliar Weight |
244.2875
| Monoisotopic Molecliar Weight |
244.142307138
| IUPAC Name |
1-(2-amino-4-methylpentanoyl)-4-hydroxypyrrolidine-2-carboxylic acid
| Traditional Name |
1-(2-amino-4-methylpentanoyl)-4-hydroxypyrrolidine-2-carboxylic acid
| CAS Registry Number |
Not Available
| SMILES |
CC(C)CC(N)C(=O)N1CC(O)CC1C(O)=O
| InChI Identifier |
InChI=1S/C11H20N2O4/c1-6(2)3-8(12)10(15)13-5-7(14)4-9(13)11(16)17/h6-9,14H,3-5,12H2,1-2H3,(H,16,17)
| InChI Key |
JCCZCUUYYHWRGX-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Leucine and derivatives
Proline and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Pyrrolidine carboxylic acids
N-acylpyrrolidines
Tertiary carboxylic acid amides
Secondary alcohols
Amino acids
Azacyclic compounds
Carboxylic acids
Monocarboxylic acids and derivatives
Organic oxides
Carbonyl compounds
Hydrocarbon derivatives
Organopnictogen compounds
Monoalkylamines
| Substituents |
Alpha-dipeptide
Leucine or derivatives
N-acyl-alpha amino acid or derivatives
Proline or derivatives
N-acyl-alpha-amino acid
Alpha-amino acid amide
Alpha-amino acid or derivatives
N-acylpyrrolidine
Pyrrolidine carboxylic acid
Pyrrolidine carboxylic acid or derivatives
Pyrrolidine
Tertiary carboxylic acid amide
Amino acid or derivatives
Carboxamide group
Amino acid
Secondary alcohol
Carboxylic acid
Azacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Alcohol
Organonitrogen compound
Organooxygen compound
Primary amine
Primary aliphatic amine
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organopnictogen compound
Amine
Organic oxygen compound
Organic nitrogen compound
Aliphatic heteromonocyclic compound
| Molecliar Framework |
Aliphatic heteromonocyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.0Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility45.3 mg/mLALOGPS
logP-2.3ALOGPS
logP-3ChemAxon
logS-0.73ALOGPS
pKa (Strongest Acidic)3.75ChemAxon
pKa (Strongest Basic)8.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area103.86 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity60.48 m3·mol-1ChemAxon
Polarizability25.19 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28930
| Metagene Link |
HMDB28930
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: R121919
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
Not Available |
PMID: 21353664
