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Isoleucyl-Cysteine

July 21, 2017
Common Name

Isoleucyl-Cysteine Description

Isoleucyl-Cysteine is a dipeptide composed of isoleucine and cysteine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite. Structure

MOLSDF3D-SDFPDBSMILESInChI View 3D Structure

Structure for HMDB28904 (Isoleucyl-Cysteine)

Synonyms

Value Source I-C dipeptideHMDB IC dipeptideHMDB Ile-cysHMDB Isoleucine cysteine dipeptideHMDB Isoleucine-cysteine dipeptideHMDB IsoleucylcysteineHMDB L-Isoleucyl-L-cysteineHMDB

Chemical Formlia

C9H18N2O3S Average Molecliar Weight

234.316 Monoisotopic Molecliar Weight

234.103813142 IUPAC Name

2-(2-amino-3-methylpentanamido)-3-slifanylpropanoic acid Traditional Name

2-(2-amino-3-methylpentanamido)-3-slifanylpropanoic acid CAS Registry Number

Not Available SMILES

CCC(C)C(N)C(=O)NC(CS)C(O)=O

InChI Identifier

InChI=1S/C9H18N2O3S/c1-3-5(2)7(10)8(12)11-6(4-15)9(13)14/h5-7,15H,3-4,10H2,1-2H3,(H,11,12)(H,13,14)

InChI Key

JSZMKEYEVLDPDO-UHFFFAOYSA-N Chemical Taxonomy Description

This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Kingdom

Chemical entities Super Class

Organic compounds Class

Organic acids and derivatives Sub Class

Carboxylic acids and derivatives Direct Parent

Dipeptides Alternative Parents

  • Isoleucine and derivatives
  • N-acyl-alpha amino acids
  • Cysteine and derivatives
  • Alpha amino acid amides
  • N-acyl amines
  • Secondary carboxylic acid amides
  • Amino acids
  • Monocarboxylic acids and derivatives
  • Carboxylic acids
  • Alkylthiols
  • Organopnictogen compounds
  • Organic oxides
  • Monoalkylamines
  • Hydrocarbon derivatives
  • Carbonyl compounds

    • Substituents

  • Alpha-dipeptide
  • Isoleucine or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • Cysteine or derivatives
  • Alpha-amino acid or derivatives
  • Fatty amide
  • N-acyl-amine
  • Fatty acyl
  • Amino acid or derivatives
  • Carboxamide group
  • Amino acid
  • Secondary carboxylic acid amide
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Alkylthiol
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Organic nitrogen compound
  • Organic oxide
  • Primary aliphatic amine
  • Organopnictogen compound
  • Carbonyl group
  • Amine
  • Organooxygen compound
  • Organoslifur compound
  • Primary amine
  • Organic oxygen compound
  • Aliphatic acyclic compound

    • Molecliar Framework

    Aliphatic acyclic compounds External Descriptors

    Not Available Ontology Status

    Expected but not Quantified Origin

  • Endogenous

    • Biofunction

    Not Available Application

    Not Available Cellliar locations

    Not Available Physical Properties State

    Solid Experimental Properties

    Property Value Reference Melting PointNot AvailableNot Available Boiling PointNot AvailableNot Available Water SolubilityNot AvailableNot Available LogP-2.0Extrapolated

    Predicted Properties

    Property Value Source Water Solubility2.69 mg/mLALOGPS logP-1.6ALOGPS logP-2ChemAxon logS-1.9ALOGPS pKa (Strongest Acidic)3.87ChemAxon pKa (Strongest Basic)8.49ChemAxon Physiological Charge0ChemAxon Hydrogen Acceptor Count4ChemAxon Hydrogen Donor Count4ChemAxon Polar Surface Area92.42 Å2ChemAxon Rotatable Bond Count6ChemAxon Refractivity59.12 m3·mol-1ChemAxon Polarizability24.59 Å3ChemAxon Number of Rings0ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon

    Spectra Spectra

    Not Available Biological Properties Cellliar Locations

    Not Available Biofluid Locations

    Not Available Tissue Location

    Not Available Pathways

    Not Available Normal Concentrations Not Available Abnormal Concentrations

    Not Available Associated Disorders and Diseases Disease References

    None Associated OMIM IDs

    None External Links DrugBank ID

    Not Available DrugBank Metabolite ID

    Not Available Phenol Explorer Compound ID

    Not Available Phenol Explorer Metabolite ID

    Not Available FoodDB ID

    Not Available KNApSAcK ID

    Not Available Chemspider ID

    Not Available KEGG Compound ID

    Not Available BioCyc ID

    Not Available BiGG ID

    Not Available Wikipedia Link

    Not Available NuGOwiki Link

    HMDB28904 Metagene Link

    HMDB28904 METLIN ID

    Not Available PubChem Compound

    Not Available PDB ID

    Not Available ChEBI ID

    Not Available

    Product: Thiomyristoyl

    References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Not Available General References
    1. Duerfahrt T, Eppelmann K, Muller R, Marahiel MA: Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem Biol. 2004 Feb;11(2):261-71. [PubMed:15123287 ]
    2. Ishihara H, Shimura K: Further evidence for the presence of a thiazoline ring in the isoleucylcysteine dipeptide intermediate in bacitracin biosynthesis. FEBS Lett. 1988 Jan 4;226(2):319-23. [PubMed:3338562 ]

    PMID: 16915381

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