| Common Name |
Glutamyl-Proline
| Description |
Glutamyl-Proline is a dipeptide composed of glutamate and proline. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB28827 (Glutamyl-Proline)
| Synonyms |
| Value |
Source |
e-P DipeptideHMDB
EP dipeptideHMDB
Glu-proHMDB
Glutamate proline dipeptideHMDB
Glutamate-proline dipeptideHMDB
GlutamylprolineHMDB
L-Glutamyl-L-prolineHMDB
| Chemical Formlia |
C10H15N2O5
| Average Molecliar Weight |
243.2365
| Monoisotopic Molecliar Weight |
243.0980966
| IUPAC Name |
4-amino-5-(2-carboxypyrrolidin-1-yl)-5-oxopentanoate
| Traditional Name |
4-amino-5-(2-carboxypyrrolidin-1-yl)-5-oxopentanoate
| CAS Registry Number |
Not Available
| SMILES |
NC(CCC([O-])=O)C(=O)N1CCCC1C(O)=O
| InChI Identifier |
InChI=1S/C10H16N2O5/c11-6(3-4-8(13)14)9(15)12-5-1-2-7(12)10(16)17/h6-7H,1-5,11H2,(H,13,14)(H,16,17)/p-1
| InChI Key |
YBTCBQBIJKGSJP-UHFFFAOYSA-M
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Proline and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Pyrrolidine carboxylic acids
N-acylpyrrolidines
Heterocyclic fatty acids
Dicarboxylic acids and derivatives
Tertiary carboxylic acid amides
Amino acids
Carboxylic acid salts
Azacyclic compounds
Carboxylic acids
Organopnictogen compounds
Hydrocarbon derivatives
Monoalkylamines
Carbonyl compounds
Organic oxides
Organic salts
Organic anions
| Substituents |
Alpha-dipeptide
N-acyl-alpha-amino acid
Proline or derivatives
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
Alpha-amino acid or derivatives
N-acylpyrrolidine
Pyrrolidine carboxylic acid
Pyrrolidine carboxylic acid or derivatives
Heterocyclic fatty acid
Dicarboxylic acid or derivatives
Fatty acyl
Fatty acid
Tertiary carboxylic acid amide
Pyrrolidine
Amino acid or derivatives
Carboxamide group
Carboxylic acid salt
Amino acid
Organoheterocyclic compound
Azacycle
Carboxylic acid
Organic oxygen compound
Organic salt
Hydrocarbon derivative
Organic oxide
Primary aliphatic amine
Organopnictogen compound
Organonitrogen compound
Organooxygen compound
Primary amine
Carbonyl group
Organic nitrogen compound
Amine
Organic anion
Aliphatic heteromonocyclic compound
| Molecliar Framework |
Aliphatic heteromonocyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.73Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility97.9 mg/mLALOGPS
logP-2.9ALOGPS
logP-3.7ChemAxon
logS-0.43ALOGPS
pKa (Strongest Acidic)3.29ChemAxon
pKa (Strongest Basic)8.44ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area123.76 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity67.11 m3·mol-1ChemAxon
Polarizability23.16 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28827
| Metagene Link |
HMDB28827
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: Cholesterol myristate
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
Not Available |
PMID: 22553035
