As expected, ERAD inhibition enhances retention of unstable GC in the ER and ultimately results in enhanced lysosomal trafficking and activity, but it also leads to significant UPR induction and apoptosis
Relative mRNA expression amounts of Bcl2 in GD JNJ-42165279 fibroblasts incubated with siRNA for forty eight hrs and handled with lacidipine (ten mM) and EerI (six mM) for added 24…