These flaws are also very likely to impair the application of piPS cells for the regenerative medicine and transgenic animal analysis [279]. Additionally, the persistent expression of retroviral reprogramming genes might also disturb the expression pattern of downstream genes
Polymer-triggering mutations (these as the a1AT Z mutant) impact the folding pathway by growing the lifetime of a polymergenic folding intermediate. Serpin polymers are favored when secondary structural domain swaps…