For that reason, in addition to subcellular localization, the post-translational modifications that ICP0 undergoes in just about every of the respective subcellular compartments likely also participate in a purpose in dictating operate
On top of that, proteasome activity was not required for cytoplasmic ICP0 action. As SeV induces the proteasome-mediated degradation of IRF3 at late occasions article-infection [ten,eleven], it is probably thatbuy…