Mice that had been null mutants for arginase-2 (A2ko null mice) had been offered by Dr. William O’Brien (Baylor School of Medicine, Houston, TX, Usa) and crossed on to the mdx background in our lab
We then assessed whether macrophages that specific arginase-2 are current in the fibrotic lesio844903-58-8ns of mdx muscle, and no matter whether their arginase expression is modulated by cytokines that promote…